Results 61 to 70 of about 229,923 (267)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

A study on the influence of communication state of wireless coupling system on heavy haul train and its operation

机车电传动, 2023
The communication delay or interruption of the wireless coupling control system would seriously affect the braking and release performance of a train, undermining its operation safety. For the purpose of this paper, the 10,000 t heavy haul formation of 2×
LIU Huawei, LIU Boyang, ZHU Jichao, AN Erjing, WEI Wei   +4 more
doaj  

A Secure Hybrid Satellite-Terrestrial Communication Network With AF/DF and Relay Selection

IEEE Access, 2019
This paper makes research on a secure hybrid satellite-terrestrial communication network with eavesdroppers at the primary and secondary receivers. To secure the transmitted messages, we adopt the null space beamforming to the amplified-and-forward (AF ...
Ruiyang Xu, Xinyu Da, Hang Hu, Lei Ni, Yu Pan   +4 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

A Human-in-the-Loop Study of Eye-Movement-Based Control for Workload Reduction in Delayed Teleoperation of Ground Vehicles

Machines
Teleoperated ground vehicles (TGVs) are widely applied in hazardous and dynamic environments, where communication delay and low transparency increase operator workload and reduce control performance.
Qiang Zhang, Aiping Zhao, Feng Zhao, Wangyu Wu   +3 more
doaj   +1 more source

Deciding Your Own Anonymity: User-Oriented Node Selection in I2P

IEEE Access, 2018
With the development of Internet applications, anonymous communication technology plays a very significant role in protecting personal privacy. As one of the most popular anonymous communication systems, I2P provides strong anonymity through its ...
Lin Ye, Xiangzhan Yu, Junda Zhao, Dongyang Zhan, Xiaojiang Du, Mohsen Guizani   +5 more
doaj   +1 more source

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source

A Distributed Optimization Approach for Multi-Agent Systems over Delaying Networks

International Journal of Information and Communication Technology Research, 2021
This paper investigates a novel method to solve distributed optimization problems in the presence of communication delays between the networked agents that cooperate together to find an optimal solution of a global cost function composed of local ones ...
Farshad Rahiimi
doaj  

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source