Results 111 to 120 of about 954,961 (363)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

open access: yesAdvanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge   +21 more
wiley   +1 more source

Dialogue of Teenager with a Virtual Interlocutor as Mediation in the Development of Communicative Competence

open access: yesПсихолого-педагогические исследования, 2018
The article describes a new methodological approach to formation of communicative competence of a teenager by means of dialogue with a virtual interlocutor.
Maslova A.A.
doaj   +1 more source

Розвиток іншомовної комунікативної компетенції у контексті рекомендацій Ради Європи з мовної освіти (Foreign language communicative competence formation according to Common European framework of reference for languages) [PDF]

open access: yes, 2016
У статті аналізуються основні методики формування іншомовної комунікативної компетенції студентів немовних ВНЗ. Поточнюється поняття комунікативної компетенції,аналізуться різні точки зору щодо значущості окремих складових зазначеної компетенції ...
Лесневська, К. (K. Lesnevska)
core  

Nurr1 Orchestrates Claustrum Development and Functionality

open access: yesAdvanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan   +12 more
wiley   +1 more source

English Task To Develop The Students’ Communicative Competence: A Study Of Edukatif Work Book For Junior High School Students [PDF]

open access: yes, 2012
This research is mainly intended to find out the extent tasks in Edukatif work books are designed to develop the students’ communicative competence. The objective of this research is to explain what extent the tasks in Edukatif work books are designed to
Rohmawati, Dyah
core  

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

open access: yesAdvanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Creencias de los estudiantes en torno a los Espacios Virtuales de Aprendizaje en el desarrollo de la competencia comunicativa oral. Un estudio de caso [PDF]

open access: yes, 2019
Oral communicative competence is traditionally neglected in the development of competence of students in compulsory education. In a highly demanding social and professional context, we must contribute to communication skills in general and to oral skills
Corpas Martos, Alberto   +1 more
core   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

open access: yesAdvanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim   +6 more
wiley   +1 more source

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