Results 71 to 80 of about 19,818 (296)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

E-Communicator; 2007-2008 No. 02

open access: yes, 2007
Vanderbilt University Divinity School newsletter.Divinity ...
Vanderbilt Divinity School
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

E-Communicator; 2007-2008 No. 03

open access: yes, 2007
Vanderbilt University Divinity School newsletter.Divinity ...
Vanderbilt Divinity School
core  

Model of electromagnetic interference in an UHF power amplifier

open access: yesТехнологія та конструювання в електронній апаратурі, 2004
An electrodynamically justified model of a balanced UHF-band power amplifier is proposed. The analysis of the amplifier was performed based on the systematic application of complex structure decomposition and calculations based on the analogy of plane ...
V. G. Kudrya
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

E-Communicator; 2007-2008 No. 06

open access: yes, 2007
Vanderbilt University Divinity School newsletter.Divinity ...
Vanderbilt Divinity School
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

E-Communicator; 2007-2008 No. 14

open access: yes, 2008
Vanderbilt University Divinity School newsletter.Divinity ...
Vanderbilt Divinity School
core  

Who works in science communication? Identifying and characterising professional profiles in Spain

open access: yesEstudios sobre el Mensaje Periodístico
This research aimed at understanding the professional contexts of science communicators in Spain and at identifying which profiles emerged when exploring the group from a multidimensional perspective.
Núria Saladié   +2 more
doaj   +1 more source

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