Results 71 to 80 of about 388,394 (322)

A framework to decipher the genetic architecture of combinations of complex diseases: applications in cardiovascular medicine [PDF]

arXiv, 2020
Genome-wide association studies(GWAS) have proven to be highly useful in revealing the genetic basis of complex diseases. At present, most GWAS are studies of a particular single disease diagnosis against controls. However, in practice, an individual is often affected by more than one condition/disorder.
arxiv  

ADAPT NXT: Fixed Cycles or Every‐Other‐Week IV Efgartigimod in Generalized Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This phase 3b, open‐label, randomized ADAPT NXT study investigated the efficacy, safety, and tolerability of efgartigimod administered in either a fixed cycles dosing regimen (3 cycles of 4 once‐weekly infusions, with 4 weeks between cycles) or a cycle followed by every‐other‐week (Q2W) dosing.
Ali A. Habib, Kristl G. Claeys, Vera Bril, Yessar Hussain, Kelly Gwathmey, Gregory Sahagian, Elena Cortés‐Vicente, Edward Brauer, Deborah Gelinas, Anne Sumbul, Rosa H. Jimenez, Daniela Hristova, Delphine Masschaele, Renato Mantegazza, Andreas Meisel, Shahram Attarian, On behalf of the ADAPT NXT Study Group   +16 more
wiley   +1 more source

Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study

Frontiers in Medicine
ObjectiveTo investigate the association between polycystic ovary syndrome (PCOS) and inflammatory proteins, and to identify and quantify the role of serum metabolites as potential mediators.MethodsUtilizing summary-level data from a genome-wide ...
Ming-Jie Jia, Li Zhou, Xing-Ning Liu, Hui-Lin Li   +3 more
doaj   +1 more source

Comorbidities in Cushing’s disease [PDF]

Pituitary, 2015
Cushing's disease is a rare disorder characterized by overproduction of ACTH from a pituitary adenoma leading to hypercortisolemia that in turn leads to increased morbidity and mortality.Here we review the comorbidities associated with Cushing's disease and their impact on quality of life and mortality.Recent evidence suggests that correction of ...
Susmeeta T. Sharma, Richard A Feelders, Lynnette K. Nieman   +2 more
openaire   +2 more sources

National Institute of Health and Care Excellence Clinical Criteria for the Diagnosis of Knee Osteoarthritis: A Prospective Diagnostic Accuracy Study in Individuals With Type 2 Diabetes

Arthritis Care &Research, EarlyView.
Objective The National Institute of Health and Care Excellence (NICE) criteria for osteoarthritis (OA) obviate the need for physical examination or imaging, and their use may improve timely diagnosis of OA. However, they have not been validated. Methods Within a larger study of individuals with type 2 diabetes, participants with and without self ...
Lauren K. King, Ian Stanaitis, Vivian Hung, Sahil Koppikar, Esther J. Waugh, Lorraine Lipscombe, Gillian A. Hawker   +6 more
wiley   +1 more source

Quantifying age- and gender-related diabetes comorbidity risks using nation-wide big claims data [PDF]

arXiv, 2013
Currently emerging "big data" techniques are reshaping medical science into a data science. Medical claims data allow assessing an entire nation's health state in a quantitative way, in particular with regard to the occurrences and consequences of chronic and pandemic diseases like diabetes. We develop a quantitative, statistical approach to test for
arxiv  

Incidence of and Risk of Mortality After Hip Fractures in Rheumatoid Arthritis Relative to the General Population

Arthritis Care &Research, EarlyView.
Objective Osteoporosis, a known complication of rheumatoid arthritis (RA), increases the risk of hip fracture, which is associated with high morbidity and mortality. Fracture risk estimates in patients with RA treated with contemporary treatment strategies are lacking.
C. Allyson Jones, Pierre Guy, Hui Xie, Eric C. Sayre, Kai Zhao, Diane Lacaille   +5 more
wiley   +1 more source

The effect of comorbidity on the use of adjuvant chemotherapy and survival from colon cancer: a retrospective cohort study

BMC Cancer, 2009
Background Comorbidity has a well documented detrimental effect on cancer survival. However it is difficult to disentangle the direct effects of comorbidity on survival from indirect effects via the influence of comorbidity on treatment choice.
Purdie Gordon, Robson Bridget, Blakely Tony, Hill Sarah, Sarfati Diana, Dennett Elizabeth, Cormack Donna, Dew Kevin   +7 more
doaj   +1 more source

Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink

Arthritis Care &Research, EarlyView.
Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged ≥65 years. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Participants were aged ≥65 years registered with a UK general practice for at least 12 months between 1998 and 2018.
Jaspreet Kaur, Georgina Nakafero, Abhishek Abhishek, Christian Mallen, Michael Doherty, Weiya Zhang   +5 more
wiley   +1 more source

Laparoscopic versus open resection for stage II/III rectal cancer in obese patients: A multicenter propensity score‐based analysis of short‐ and long‐term outcomes

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 71-80, January 2023., 2023
Kaplan‐Meier plot for relapse‐free survival (RFS) after propensity score (PS) matching. Abstract Aim Whether a laparoscopic procedure can contribute to the improvement of clinical outcomes in obese patients with stage II/III rectal cancer compared to an open procedure remains unclear.
Tomonori Akagi, Kentaro Nakajima, Yasumitsu Hirano, Tomoya Abe, Ryo Inada, Yohei Kono, Hidefumi Shiroshita, Tetsuji Ohyama, Masafumi Inomata, Seiichiro Yamamoto, Takeshi Naitoh, Yoshiharu Sakai, Masahiko Watanabe, the Japan Society of Laparoscopic Colorectal Surgery   +13 more
wiley   +1 more source