Results 191 to 200 of about 344,988 (202)

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Equity in Action: Disrupting Systemic Barriers to Specialty Skill Utilisation Among Internationally Qualified Nurses in Australia. [PDF]

Nurs Open
Kurup C, Burston AS, Betihavas V, Jacob ER.   +3 more
europepmc   +1 more source

Show Me Competence or Make Me Feel Warm: The Impact of Green Brand Anthropomorphism on Consumers' Purchasing Intentions. [PDF]

Behav Sci (Basel)
Li S, Chang H, Ma J, Chen K.
europepmc   +1 more source

Psychosocial Determinants Among Hospital and Primary Healthcare Professionals Towards Cancer and Cancer Patients in Croatia. [PDF]

J Clin Med
Kotromanovic D, Kotromanovic Simic I, Lovrincevic Pavlovic N, Olujic M, Spajic S, Peric L, Cvijic Peric T, Matic Licanin M, Tomas I, Miskulin I.   +9 more
europepmc   +1 more source

Public versus private clinical radiography training in Lagos State, Nigeria: a comparative cross-sectional survey of associations with graduate self-perceived competence and practice readiness. [PDF]

BMJ Open
Udo EO, Emordi OR, Kalu EI, Enebeli UU, Uzochukwu B, Kalu FA, Igwe PC, Kalu JJ, Kalu BO, Cherima YJ, Nwokenna US, Hassan RK, Amadi AN.   +12 more
europepmc   +1 more source

The effect of basic psychological needs in physical education on exercise behavior in young adulthood: the mediating role of self-efficacy and moderated role of gender. [PDF]

Front Psychol
Li X, Wang D, Xie W, Wang J.
europepmc   +1 more source

Impact of Death Work Competence on Emergency Nurses' Perspectives in the Organ Donation Process. [PDF]

Indian J Crit Care Med
Jose S, Cyriac MC, Dhandapani M, Gayathri PV.   +3 more
europepmc   +1 more source

An AI-Driven Virtual Patient Platform (CBT Trainer) for Training Cognitive Behavioral Therapy Practitioners Against Competencies: Mixed Methods Pilot Study.

JMIR Med Educ
Zhang TT, Saunders R, Pilling S, O'Driscoll C.   +3 more
europepmc   +1 more source