Results 81 to 90 of about 465,738 (247)
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Le Programme international pour le suivi des acquis des élèves (PISA)
Revue Internationale d’Éducation de Sèvres, 2006 The PISA programme, organized by the joint decision of OECD countries, aims at assessing, within a common conceptual framework, the performances of educational systems in keeping with the way they prepare fifteen-year-olds to adult life.
Jacqueline Levasseur
doaj +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Se former, certes..., mais comment ?
Revue Internationale d’Éducation de Sèvres, 1997 Sur un fond de description analytique de procédures et de questionnement du lecteur, est proposée une étude sur l’obligation que représente pour l’entreprise et ses acteurs une démarche de formation tout au long de la vie.
Yves Michel
doaj +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
DE LA CONNAISSANCE A LA MAITRISE DU RISQUE : COMMENT SE CONSTRUIT LA COMPETENCE DU COMMISSAIRE AUX COMPTES ? [PDF]
La compétence renvoie à un " savoir agir reconnu " dans la mesure où elle témoigne de la capacité d'un individu à accomplir certaines tâches (LE BOTERF). La compétence se distingue ainsi de l'action et du résultat de l'action.
Christine Noël
core
L'évaluation sommative de l'interprétation simultanée: une réflexion sur les objectifs, les critéres et sur les risques d'erreur [PDF]
, 2009 L’évaluation de l’interprétation simultanée en fin de parcours constitue encore aujourd’hui un défi tant au niveau théorique qu’au niveau de son application didactique.
Pippa, Salvador
core +1 more source
Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley +1 more source