Results 31 to 40 of about 159,384 (275)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Guide d’annotation des compétences techno-semio-pédagogiques
, 2021 Guide d’annotation des compétences techno-semio-pédagogiques de tuteurs et tutrices en ligne. Ce guide pratique contient le guide d'annotation, les conseils d'utilisation du logiciel Elan et la méthodologie du contre ...
Tellier, Marion
core +2 more sources
Analyse des items de TENAFEP en République Démocratique du Congo (2003-2010)
Revue Congolaise des Sciences et Technologies, 2022 Cette analyse porte sur des questions écrites posées au test de fin d’études primaires, dénommée TENAFEP, ciblant les élèves de plus ou moins douze ans.
Peter Muamba Yombo
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Revue Congolaise des Sciences et Technologies, 2022 Le présent article est un outil pédagogique dont la construction est décrite de manière pratique sur base de l’approche par les Situations partant des difficultés éprouvées par les apprenants pendant leurs premières années de scolarité. Cet outil qui est
Peter Muamba Yombo, Jacques Phaka Ngimbi
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Glottodidactica, 2022 The aim of the text is to discuss the possibilities of developing professional self-awareness at the stage of initial education of foreign language teachers.
Jolanta Sujecka-Zając +1 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Revue Internationale de Pédagogie de l’Enseignement Supérieur, 2018 Faced with a massive influx of students without a common educational foundation and background, the issue of knowledge transfer and of the development of teaching practices in higher education is currently at the crux of the debate.
Perrine Martin, Philippe Padula
doaj +1 more source