Results 31 to 40 of about 929,842 (311)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Dual-Flow Structure to Design a Continuous and Compact Nature Reserve

IEEE Access, 2019
Establishing the conservation reserves is an efficient approach to protect various species, in which maintaining the spatial characteristics of the habit is an important issue.
Chih-Wei Lin, Wei-Hao Tu, Jin-Fu Liu
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Overview of EXL-50 research progress

Nuclear Fusion
XuanLong-50 (EXL-50) is the first medium-size spherical torus (ST) in China, with the toroidal field of 0.5 T at a major radius of 50 cm. Central Solenoid (CS)—free and non-inductive current drive via electron cyclotron resonance heating (ECRH) were the ...
Yuejiang Shi, Yumin Wang, Bing Liu, Xianming Song, Shaodong Song, Xinchen Jiang, Dong Guo, Di Luo, Xiang Gu, Tiantian Sun, Xianli Huang, Zhi Li, Lili Dong, Xueyun Wang, Gang Yin, Mingyuan Wang, Wenjun Liu, Hanyue Zhao, Huasheng Xie, Liu Yong, Dongkai Qi, Bo Xing, Jiangbo Ding, Chao Wu, Lei Li, Haijun Zhang, Yuanming Yang, Xin Zhao, Enwu Yang, Wenwu Luo, Peihai Zhou, Lei Han, Qing Zhou, Hanqing Wang, Jiaqi Dong, Baoshan Yuan, Y.-K. Martin Peng, Minsheng Liu, the EXL-50 team   +38 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Design of Ultracompact High‐Speed‐Integrated Lithium–Niobate Periodic Dielectric Waveguide Modulator

Advanced Photonics Research, 2022
Modern communications and microwave photonics require compact electro‐optic modulators with ultrahigh bandwidth and low power consumption. These requirements can be satisfied by integrated lithium–niobate electro‐optic modulators with high bandwidth and ...
Yifan Qi, Zheng Zhang, Wenhe Jia, Sai Chen, Yuanmu Yang, Yang Li   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

High-Performance Ultra-Compact Dual-Band Bandpass Filter for Global System for Mobile Communication-850/Global System for Mobile Communication-1900 Applications

ARO-The Scientific Journal of Koya University, 2019
This work presents a novel microstrip dual-band bandpass filter (BPF) using meandros spirals and patch cells, which is proposed for the first time by this work. It occupies a very compact size of 0.0017 λg2.
Abbas Rezaei, Salah I. Yahya
doaj   +1 more source