Results 31 to 40 of about 373,425 (266)
, 2018 The compact-table propagator for table constraints appears to be a strong candidate for inclusion into any constraint solver due to its efficiency and simplicity. However, successful integration into a constraint solver based on copying rather than trailing is not obvious: while the underlying bit-set data structure is sparse for efficiency it is not ...
Linnea Ingmar, Christian Schulte 0001
openaire +3 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Overview of EXL-50 research progress
Nuclear FusionXuanLong-50 (EXL-50) is the first medium-size spherical torus (ST) in China, with the toroidal field of 0.5 T at a major radius of 50 cm. Central Solenoid (CS)—free and non-inductive current drive via electron cyclotron resonance heating (ECRH) were the ...
Yuejiang Shi +38 more
doaj +1 more source
Design of Ultracompact High‐Speed‐Integrated Lithium–Niobate Periodic Dielectric Waveguide Modulator
Advanced Photonics Research, 2022 Modern communications and microwave photonics require compact electro‐optic modulators with ultrahigh bandwidth and low power consumption. These requirements can be satisfied by integrated lithium–niobate electro‐optic modulators with high bandwidth and ...
Yifan Qi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
ARO-The Scientific Journal of Koya University, 2019 This work presents a novel microstrip dual-band bandpass filter (BPF) using meandros spirals and patch cells, which is proposed for the first time by this work. It occupies a very compact size of 0.0017 λg2.
Abbas Rezaei, Salah I. Yahya
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source