Results 51 to 60 of about 46,896 (216)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Design and analysis of a complementary split ring resonator (CSRR) metamaterial based antenna for wideband application

Science and Engineering of Composite Materials, 2017
In this article, a compact complementary split ring resonator (CSRR) based double-negative (DNG) metamaterial antenna is presented for wideband (4.49 GHz–21.85 GHz) wireless application.
Islam Sikder Sunbeam, Alam Touhidul, Iqbal Faruque Mohammad Rashed, Islam Mohammad Tariqul   +3 more
doaj   +1 more source

A Compact Transmission-Line Self-Matched Negative Group Delay Microwave Circuit

IEEE Access, 2017
A compact self-matched negative group delay (NGD) circuit without the need for an external matching circuit is proposed. The proposed NGD circuit is composed of two-port open-circuited coupled lines, a short-circuited transmission line and two resistors ...
Te Shao, Zhongbao Wang, Shaojun Fang, Hongmei Liu, Shiqiang Fu   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

EFIT-mini: an embedded, multi-task neural network-driven equilibrium inversion algorithm

Nuclear Fusion
This paper presents EFIT-mini, a novel equilibrium reconstruction algorithm which integrates neural networks with physical simulation, enabling real-time plasmas control in the EXL-50U tokamak.
G.H. Zheng, S.F. Liu, H.S. Xie, X. Gu, Z.Y. Chen, X.C. Lun, Y. Liu, J. Li, D. Guo, R.Y. Tao, H.Y. Zhao, Y.P. Zhang, T.T. Sun, Y.N. Xu, Y.J. Hu, Z.Y. Yang   +15 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

An investigation of a realization method for High Load Capacity and Compact Mechanical Gravity Canceller with tension transmission function via two rotational axes

Nihon Kikai Gakkai ronbunshu, 2019
This study aims at realization of Mechanical Gravity Canceller with tension transmission function via two rotational axes, which achieves a good balance between suitability for M-DOF and high load capacity.
Yutaka FUKADA, Kazuki KANEDA, Toshio MORITA   +2 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source