Results 41 to 50 of about 1,358,497 (293)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Compact SPICE Model for TeraFET Resonant Detectors

Micromachines
This paper presents an improved compact model for TeraFETs employing a nonlinear transmission line approach to describe the non-uniform carrier density oscillations and electron inertia effects in the TeraFET channels.
Xueqing Liu, Yuhui Zhang, Trond Ytterdal, Michael Shur   +3 more
doaj   +1 more source

Fast and Expandable ANN-Based Compact Model and Parameter Extraction for Emerging Transistors

IEEE Journal of the Electron Devices Society, 2023
In this paper, we present a fast and expandable artificial neural network (ANN)-based compact model and parameter extraction flow to replace the existing complicated compact model implementation and model parameter extraction (MPE) method. In addition to
Hyunjoon Jeong, Sangmin Woo, Jinyoung Choi, Hyungmin Cho, Yohan Kim, Jeong-Taek Kong, Soyoung Kim   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Flowing sand - a possible physical realization of Directed Percolation

, 1999
A simple model for flowing sand on an inclined plane is introduced. The model is related to recent experiments by Douady and Daerr [Nature 399, 241 (1999)] and reproduces some of the experimentally observed features.
Domany, Eytan, Hinrichsen, Haye, Jimenez-Dalmaroni, Andrea, Rozov, Yadin   +3 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Compact oscillons in the signum-Gordon model

, 2007
We present explicit solutions of the signum-Gordon scalar field equation which have finite energy and are periodic in time. Such oscillons have a strictly finite size.
H. Arodź, H. Arodź, H. Arodź, H. Arodź, H. Arodź, H. Arodź, H. Arodź, L. C. Evans, P. Klimas, R. D. Richtmyer, T. Tyranowski   +10 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Ternary CMOS Compact Model for Low Power On-Chip Memory Applications

IEEE Journal of the Electron Devices Society
In this work, we present a tunneling based ternary CMOS (T-CMOS) compact model for low power ternary-SRAM (T-SRAM) design using CMOS technology. By designing compact model parameters of band-to-band tunneling current $(I_{\mathrm { BTBT}})$ according ...
Young-Eun Choi, Woo-Seok Kim, Myoung Kim, Junyoung Park, Min Woo Ryu, Kyung Rok Kim   +5 more
doaj   +1 more source

A nonlinear scalar model of extreme mass ratio inspirals in effective field theory I. Self force through third order

, 2010
The motion of a small compact object in a background spacetime is investigated in the context of a model nonlinear scalar field theory. This model is constructed to have a perturbative structure analogous to the General Relativistic description of ...
Ajith P, Barack L, Baumann D Nicolis A Senatore L Zaldarriaga M, Bollini C G, Burke W L, Chad R Galley, Damour T, Danzmann K, Detweiler S, Drasco S, Flanagan E E Hinderer T, Gair J R, Galley C R, Galley C R, Gralla S E, Hadamard J, Infeld L, Keldysh L V, Keldysh L V, Landau L D, Levi M, Levi M, Lousto C O Zlochower Y, Perrodin D L, Poisson E, Porto R A, Porto R A Ross A Rothstein I Z, Porto R A Rothstein I Z, Rosenthal E, Vallisneri M, Yolcu C Rothstein I Z Deserno M, Zemanian A H   +31 more
core   +1 more source