Results 41 to 50 of about 290,773 (308)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Multi-layer graphene FET compact circuit-level model with temperature effects

, 2014
This paper presents a circuit-level model of a dual-gate bilayer and four layer graphene field effect transistor (GFET). The model provides an accurate estimation of the conductance at the charge neutrality point (CNP).
Umoh, Ime Jarlath, Kazmierski, Tom, Al-Hashimi, Bashir   +2 more
core   +1 more source

Ternary CMOS Compact Model for Low Power On-Chip Memory Applications

IEEE Journal of the Electron Devices Society
In this work, we present a tunneling based ternary CMOS (T-CMOS) compact model for low power ternary-SRAM (T-SRAM) design using CMOS technology. By designing compact model parameters of band-to-band tunneling current $(I_{\mathrm { BTBT}})$ according ...
Young-Eun Choi, Woo-Seok Kim, Myoung Kim, Junyoung Park, Min Woo Ryu, Kyung Rok Kim   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Random Action of Compact Lie Groups and Minimax Estimation of a Mean Pattern [PDF]

, 2011
This paper considers the problem of estimating a mean pattern in the setting of Grenander's pattern theory. Shape variability in a dataset of curves or images is modeled by the random action of elements in a compact Lie group on an infinite dimensional ...
Gadat, Sébastien, Bigot, Jérémie, Christophe, Claire, Claire, Christophe   +3 more
core   +1 more source

Compact electro-thermal models of interconnects [PDF]

19th International Workshop on Thermal Investigations of ICs and Systems (THERMINIC), 2013
In this paper a novel approach is proposed for generating nonlinear compact models of the dynamic electrothermal problems modeling interconnects. The method is very efficient and leads to accurate approximations of the space-time distribution of voltages, currents and temperature rises within the interconnects for all waveforms of the port variables.
openaire   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Astroparticle physics with compact objects

, 2021
Probing the existence of hypothetical particles beyond the Standard model often deals with extreme parameters: large energies, tiny cross-sections, large time scales, etc.
Pshirkov, Maxims, Sergei Popov, Popov, Sergei, Tiniakov, Petr, Peter Tinyakov, Maxim Pshirkov   +5 more
core   +1 more source

SHIP: a computational framework for simulating and validating novel technologies in hardware spiking neural networks

Frontiers in Neuroscience
Investigations in the field of spiking neural networks (SNNs) encompass diverse, yet overlapping, scientific disciplines. Examples range from purely neuroscientific investigations, researches on computational aspects of neuroscience, or applicative ...
Emanuele Gemo, Sabina Spiga, Stefano Brivio   +2 more
doaj   +1 more source