Results 61 to 70 of about 33,277 (260)
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
The Puzzling Long GRB 191019A: Evidence for Kilonova Light
The Astrophysical JournalGRB 191019A was a long gamma-ray burst (GRB) lasting ~65 s and, as such, originally thought to be linked to a core-collapse supernova. However, even though follow-up observations identified the optical counterpart close to the bright nucleus of a nearby ...
G. Stratta +13 more
doaj +1 more source
A note on separation and compactness in categories of convergence spaces
Applied General Topology, 2003 In previous papers, various notions of compact, T3, T4, and Tychonoff objects in a topological category were introduced and compared. The main objective of this paper is to characterize each of these classes of objects in the categories of filter and ...
Mehmet Baran, Muammer Kula
doaj +1 more source
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source
Lower bound on the compactness of isotropic ultracompact objects [PDF]
Physical Review D, 2018 Horizonless spacetimes describing spatially regular ultra-compact objects which, like black-hole spacetimes, possess closed null circular geodesics (light rings) have recently attracted much attention from physicists and mathematicians. In the present paper we raise the following physically intriguing question: How compact is an ultra-compact object ...
openaire +2 more sources
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
The Astrophysical JournalThe study of X-ray pulsar accretion columns helps us characterize accretion physics in this extreme regime of strong gravity and strong magnetic fields. Previous observations of the X-ray pulsar Hercules X-1 revealed a highly broadened Fe K emission line,
Peter Kosec +13 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source