Results 41 to 50 of about 34,160 (259)

Regular compact objects with scalar hair

Physical Review D, 2023
We discuss exact regular compact object solutions in higher dimensional extensions of General Relativity sourced by a phantom scalar field in arbitrary $D$ spacetime dimensions ($D>2$), for which a central singularity is absent. We follow a bottom-up approach, by means of which, by imposing the desired form of the solution to the metric function, we
Thanasis Karakasis, Nick E. Mavromatos, Eleftherios Papantonopoulos   +2 more
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Nonlinear instability and scalar clouds of spherical exotic compact objects in scalar-Gauss-Bonnet theory

European Physical Journal C: Particles and Fields, 2023
In this work, we present a new type of scalar clouds supported by spherically symmetric horizonless compact objects in the scalar-Gauss–Bonnet theory.
Shao-Jun Zhang
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Dark compact objects: An extensive overview [PDF]

Physical Review D, 2019
17pp, 11 figs, PRD in ...
Deliyergiyev, Maksym, Del Popolo, Antonino, Tolos, Laura, Le Delliou, Morgan, Lee, Xiguo, Burgio, Fiorella   +5 more
openaire   +3 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Evolution and merging of binaries with compact objects [PDF]

Physics Reports, 2007
32 pages, 1 figure, substantial changes from ...
Bethe, H. A., Brown, G. E., Lee, C. -H.
openaire   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Broad-Band Variability in Accreting Compact Objects

Acta Polytechnica CTU Proceedings, 2015
Cataclysmic variable stars are in many ways similar to X-ray binaries. Both types of systems possess an accretion disk, which in most cases can reach the surface (or event horizon) of the central compact object.
S. Scaringi
doaj   +1 more source