Results 31 to 40 of about 33,277 (260)

Black Hole Bounces on the Road to Quantum Gravity

Universe, 2018
Quantum resolutions of the space-time singularity at the end of gravitational collapse may provide hints towards the properties of a final theory of Quantum-Gravity.
Daniele Malafarina
doaj   +1 more source

Pair Creation in Hot Electrosphere of Compact Astrophysical Objects

The Astrophysical Journal
The mechanism of pair creation in the electrosphere of compact astrophysical objects such as quark stars or neutron stars is revisited, paying attention to evaporation of electrons and acceleration of electrons and positrons, which were previously not ...
Mikalai Prakapenia, Gregory Vereshchagin
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Self-consistent Disk-reflection Analysis of the Black Hole Candidate X-Ray Binary MAXI J1813−095 with NICER, Swift, Chandra, and NuSTAR

The Astrophysical Journal
We present our analysis of MAXI J1813−095 during its hard state “stalled” outburst in 2018. This self-consistent analysis has been carried out using the Neutron Star Interior Composition Explorer, Swift, Chandra, and NuSTAR throughout seven observations ...
Santiago Ubach, James F. Steiner, Jiachen Jiang, Javier García, Riley M. T. Connors, Guglielmo Mastroserio, Ye Feng, John A. Tomsick   +7 more
doaj   +1 more source

Nonlinear instability and scalar clouds of spherical exotic compact objects in scalar-Gauss-Bonnet theory

European Physical Journal C: Particles and Fields, 2023
In this work, we present a new type of scalar clouds supported by spherically symmetric horizonless compact objects in the scalar-Gauss–Bonnet theory.
Shao-Jun Zhang
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Regular compact objects with scalar hair

Physical Review D, 2023
We discuss exact regular compact object solutions in higher dimensional extensions of General Relativity sourced by a phantom scalar field in arbitrary $D$ spacetime dimensions ($D>2$), for which a central singularity is absent. We follow a bottom-up approach, by means of which, by imposing the desired form of the solution to the metric function, we
Thanasis Karakasis, Nick E. Mavromatos, Eleftherios Papantonopoulos   +2 more
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source