Results 91 to 100 of about 99,554 (305)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Sβ−COMPACTNESS IN L-TOPOLOGICAL SPACES ∗
, 2005 In this paper, the notion of Sβ−compactness is introduced in Ltopological spaces by means of open βa−cover. It is a generalization of Lowen’s strong compactness, but it is different from Wang’s strong compactness. Ultra-compactness implies Sβ−compactness.
Antofagasta Chile, Fu Gui Shi
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Proceedings of the American Mathematical Society, 2005 We initiate a study of topological orthoalgebras (TOAs), concentrating on the compact case. Examples of TOAs include topological orthomodular lattices, and also the projection lattice of a Hilbert space. As the latter example illustrates, a lattice-ordered TOA need not be a topological lattice.
openaire +3 more sources
, 2005 In this paper, the notions of countable S∗-compactness is introduced in L-topological spaces based on the notion of S∗-compactness. An S∗-compact L-set is countably S∗-compact.
Antofagasta Chile, Gui Qin Yang
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Compactness for $GSBV^p$ via concentration-compactness [PDF]
Motivated by variational models for fracture, we provide a new proof of compactness for $GSBV^p$ functions without a priori bounds on the function itself.
Feldman, William M, Stinson, Kerrek
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Countable s*-compactness in L-spaces
, 2017 In this paper, the notions of countable S*-compactness is introduced in L-topological spaces based on the notion of S*-compactness. An S*-compact L-set is countably S*-compact.
Yang, Gui-Qin
core +1 more source
A double-sigmoid model for grapevine bunch compactness development [PDF]
, 2018 Aim Bunch compactness is the result of a complex dynamic process in which many bunch, berry and rachis features interact during the whole grapevine reproductive cycle.
Javier Tello +8 more
core +1 more source