Results 101 to 110 of about 58,502 (302)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Microplastics caused embryonic growth retardation and placental dysfunction in pregnant mice by activating GRP78/IRE1α/JNK axis induced apoptosis and endoplasmic reticulum stress

Particle and Fibre Toxicology
Microplastics (MPs), a brand-new class of worldwide environmental pollutant, have received a lot of attention. MPs are consumed by both humans and animals through water, food chain and other ways, which may cause potential health risks.
Jun Bai, Yuzeng Wang, Siwei Deng, Ying Yang, Sheng Chen, Zhenlong Wu   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Home alone : diagnosis and treatment of separation anxiety

, 2014
Separation anxiety is described as problematic behaviour motivated by anxiety that occurs exclusively in the owner's absence or virtual absence. Anxiety-related disorders and separation anxiety are among the most common behavioural problems in domestic ...
C. Palestrini
core  

Does owning a companion animal influence the belief that animals experience emotions such as grief?

, 2014
This paper investigates public attitudes towards emotional experiences in animals. We surveyed 1,000 members of the public to investigate how companion animal ownership affects the attribution of emotions to animals and beliefs about whether animals can ...
Waran, N. K., McGrath, N., Walker, J. K., Handel, I. G., Phillips, C. J. C.   +4 more
core   +1 more source

Assessment of predictive value of pre- and postoperative urethral pressure profiles for long-term continence in female dogs with ectopic ureters: a preliminary study

Acta Veterinaria Scandinavica
Background Ectopic ureters (EU) are the main cause of urinary incontinence in juvenile dogs with a continence rate ranging from 22 to 72% reported after surgical correction.
Pierre Langer, Annick Hamaide, Stéphanie Noël   +2 more
doaj   +1 more source

Prevalence of osteochondral lesions in the fetlock and hock joints of Standardbred horses that survived bacterial infection before 6 months of age

BMC Veterinary Research, 2018
Background Young Standardbred horses frequently develop fragments in joints. Some fragments represent osteochondrosis; others are considered developmental, but it is uncertain whether they result from preceding osteochondrosis.
Eli H. S. Hendrickson, Sigrid Lykkjen, Nils I. Dolvik, Kristin Olstad   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

WSAVA animal welfare guidelines for veterinary practitioners and veterinary teams [PDF]

, 2019
To realise the veterinary profession’s commitment to the highest animal welfare standards, WSAVA calls on member organisations and companion animal veterinarians to: 1. develop an animal welfare charter that reflects their commitment to animal welfare. 2.
Seksel, K., Ryan, S, Takashima, G., Jouppi, R., dASS BW-2, Human Animal Relationships / One Welfare, Bacon, H., Endenburg, N., ?, ?, N. Endenburg, K. Seksel, Lee, N., S. Ryan, H. Bacon, Ryan, S., Bacon, H, Endenburg, N, G. Takashima, S. Hazel, N. Lee, Hazel, S., R. Jouppi   +21 more
core   +1 more source