Results 81 to 90 of about 58,502 (302)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Defining a “Good Death”: Exploring Veterinarians’ Perceptions of Companion Animal Euthanasia

, 2023
This study was designed to determine how veterinarians define a good euthanasia experience. This information is used to generate a working definition of companion animal euthanasia that aligns with animal welfare standards and pet owners&rsquo ...
Lori R. Kogan, Kathleen A. Cooney
core   +1 more source

Macleaya Extract versus Pregabalin Therapeutic Effectiveness for Neuropathic Pain in Dogs

Veterinary Medicine International
Dogs suffer from neuropathic pain due to several neurological disorders, particularly intervertebral disc disease. We aimed to identify alternative therapeutics for neuropathic pain relief in dogs by comparing the treatment efficacy of pregabalin and ...
Saowanee Petchnamthong, Titiyaporn Krambunlue, Nirut Suwanna   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

“Caring For Their Pet More Than Themselves”: Attitudes toward Homeless People with a Companion Animal

Homelessness is a significant social problem internationally and some people who are homeless rely on their companion animal for comfort and support. It is unknown what attitudes Australian communities have regarding people who are homeless and have a ...
Sofija, Ernesta, Downes, Marie, Downes, Martin, Maujean, Annick, Byrnes, Joshua   +4 more
core   +1 more source

Social Environment and Control Status of Companion Animal-Borne Zoonoses in Japan

, 2012
Changing social and environmental factors have been the cause of an increase in the number and variety of animals are being imported into Japan. Moreover, the number of Japanese households are keeping companion animals has also risen.
Hiromi Takahashi-Omoe, Katsuhiko Omoe
core   +1 more source

Evaluation of the vaginal and urinary microbiota of healthy cycling bitches

BMC Veterinary Research
Background While the urogenital microbiota has recently been characterized in healthy male and female dogs, the influence of sex hormones on the urogenital microbiome of bitches is still unknown.
Virginie Gronsfeld, Flore Brutinel, Sophie Egyptien, Charles Porsmoguer, Annick Hamaide, Bernard Taminiau, Georges Daube, Marie-Lys Van de Weerdt, Stefan Deleuze, Stéphanie Noel   +9 more
doaj   +1 more source