Results 111 to 120 of about 58,502 (302)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

A study of the transference between empathy towards companion animals and empathy towards humans in children [PDF]

, 2000
Plan AViolence in our society is a growing concern. There is evidence of increasing violent behavior in young children. Problems such as teasing and schoolyard bullying have turned into vicious attacks and even murder. Professionals and lay persons alike
Lind, Mary A.
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Short-term effects of pet acquisition and loss on well-being in an unbiased sample during the COVID-19 pandemic

Scientific Reports
Research on the impact of pet ownership on well-being has produced mixed results, often influenced by a focus on pet enthusiasts. To address this bias, we conducted a longitudinal study in Hungary using a stratified random sample based on gender, age ...
Judit Mokos, Eniko Kubinyi, Dorottya J. Ujfalussy, Ivaylo B. Iotchev, Borbála Paksi, Zsolt Demetrovics, Róbert Urbán, Ádám Miklósi   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Companion animal separation and loneliness

It is widely believed that companion animal ownership can help to alleviate loneliness. This study explored whether companion animal separation leads to increased levels of loneliness.
Collis, Glyn M., Gilbey, Andrew, McNicholas, June   +2 more
core   +1 more source

Companion animal death and client bereavement: A qualitative investigation of veterinary nurses’ caregiving experiences

, 2019
Veterinary paraprofessionals are routinely confronted with companion animal death and client bereavement throughout their day-to-day work. However, research exploring the nature and psychological impact of these end-of-life encounters among veterinary ...
Deacon, RE, Brough, P
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Molecular medicine for companion animal practitioners

, 2007
[Extract] Molecular biology is in the process of revolutionising medicine. Some people speak of "molecular medicine" as if it were a discipline akin to endocrinology or haematology, but this is not true.
Squires, Richard A.
core