Results 101 to 110 of about 62,869 (310)

Reduced FXR Target Gene Expression in Copper-Laden Livers of COMMD1-Deficient Dogs

open access: yesVeterinary Sciences, 2019
Wilson’s disease (WD), an autosomal recessive disorder, results in copper accumulation in the liver as a consequence of mutations in the gene ATPase copper transporting beta (ATP7B). The disease is characterized by chronic hepatitis, eventually resulting
Xiaoyan Wu   +5 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Markers of Gut Health in Small Animals: Focus on Fatty Acids and Amino Acids as Indicators of Intestinal Functionality and Microbiome Activity [PDF]

open access: yes
Chronic inflammatory enteropathies (CIEs) in companion animals represent a group of idiopathic, immune-mediated gastrointestinal disorders in which the intestinal epithelium can be altered, affecting intestinal functionality, nutrient absorption, and ...
Angel Sainz   +5 more
core   +1 more source

Forgotten, But Not Lost—Alloparental Behavior and Pup–Adult Interactions in Companion Dogs [PDF]

open access: yes, 2019
Socialization with humans is known to be a pivotal factor in the development of appropriate adult dog behavior, but the role and extent of dog–dog interactions in the first two months of life is rarely studied.
Péter Pongrácz   +3 more
core   +1 more source

Comparative proteomic profiling of the ovine and human PBMC inflammatory response

open access: yesScientific Reports
Understanding the cellular and molecular mechanisms of inflammation requires robust animal models. Sheep are commonly used in immune-related studies, yet the validity of sheep as animal models for immune and inflammatory diseases remains to be ...
A. Elkhamary   +5 more
doaj   +1 more source

Metastatic Cardiac Hemangiosarcoma in a 6 Year Old Wheaten Terrier Mix

open access: yesVeterinary Sciences, 2019
A 6 year old Wheaten Terrier mix with a history of collapse and lethargy was referred for evaluation of pericardial effusion. The echocardiogram identified pericardial effusion and a right auricular mass.
Shiori Arai   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Considerations for the Retirement of Therapy Animals [PDF]

open access: yes, 2019
With the growth of animal-assisted interventions, the number of animals designated to work as therapy animals continues to increase. These animals participate in this work in varying capacities during life, but there will be a point in time when the ...
Zenithson Y. Ng, Aubrey H. Fine
core   +1 more source

A validation study to analyze the reliability of center of pressure data in static posturography in dogs

open access: yesFrontiers in Veterinary Science
IntroductionCenter of pressure (COP) parameters are frequently assessed to analyze movement disorders in humans and animals. Methodological discrepancies are a major concern when evaluating conflicting study results.
Masoud Aghapour   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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