Results 171 to 180 of about 52,792 (267)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Current understanding of <i>Thelazia callipaeda</i> infection in Japan: Integrating data from humans, companion animals, wildlife, and vectors. [PDF]

Int J Parasitol Parasites Wildl
Tokiwa T, Doi K.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Comparative Analysis of Chemotherapy Resistance Mechanisms in Humans and Companion Animals. [PDF]

Vet Sci
Cravo DLM, Pimentel PAB, Garcia APV, Junqueira ALM, Soares FS, Giuliano A, Almendros A, Horta RDS.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Corrigendum: External mechanical perturbations challenge postural stability in dogs

Frontiers in Veterinary Science
Christiane Lutonsky, Christian Peham, Marion Mucha, Bianca Reicher, Rita Gaspar, Alexander Tichy, Barbara Bockstahler   +6 more
doaj   +1 more source

Essential Oils for Flea and Tick Control in Companion Animals: A Critical Review of Efficacy, Safety, Resistance Mitigation and Integrated Pest Management. [PDF]

Antibiotics (Basel)
Bava R, Bulotta RM, Castagna F, Ruga S, Lupia C, Conforti F, Statti G, Crupi R, Musella V, Palma E.   +9 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Analysis of the emotional bond perception between elderly guardians and health professionals with companion animals in the one health perspective. [PDF]

Open Vet J
Junior ERB, Ribeiro SO, de Lima ER, Maia RCC, Silva JCR, Junior JWP.   +5 more
europepmc   +1 more source