Results 51 to 60 of about 8,890,655 (301)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Dividend Policy, Liquidity and Company Growth on Company Value in Pharmaceutical Companies

Indonesian Journal of Innovation Studies, 2023
This study aims to examine the effect of Dividend Policy, Liquidity, and Company Growth on Firm Value. The approach used in this research is a quantitative approach. The population in this study is pharmaceutical companies listed on the Indonesia Stock Exchange.
Ella Lukmawati, Misti Hariasih
openaire   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

MAQASHID SYARIAH INDEX DAN DEWAN KOMISARIS INDEPENDEN TERHADAP NILAI PERUSAHAN DENGAN PROFITABILITAS SEBAGAI VARIABEL MEDIASI PADA PERUSAHAAN ASURANSI SYARIAH

I-Finance, 2020
This study aims to examine the effect of maqashid syariah index, an independent board of commissioners on firm value by mediating profitability. The population in this study is sharia insurance companies listed on the Indonesia Stock Exchange.
Puji Sahara, Titin Hartini, Sri Delasmi Jayanti   +2 more
doaj   +1 more source

Company Growth, Company Size, and Investment Decisions on Banking Company Value

Indonesian Journal of Innovation Studies, 2023
This study aims to examine the effect of firm growth, firm size, and investment decisions on firm value. The approach used in this research is a quantitative approach. The population in this study is banking companies listed on the Indonesia Stock Exchange. The sampling technique used purposive sampling method. The sample in this study was 72 companies
Lailatul Amelia, Detak Prapanca
openaire   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The Impact of Obesity in the UAE: Real-world Physician and Patient Perspectives

Dubai Diabetes and Endocrinology Journal
Background: Limited evidence exists on the impacts of obesity in the United Arab Emirates (UAE). Real-world evidence is required to support obesity-related healthcare decision-making in the UAE.
Rita Nawar, Rahila Bhatti, Fatih Tangi, Soniya Rai, Tatjana Isailovic, Swarna Khare, Esther Artime, Victoria Higgins, Andrea Leith, Fatheya Al Awadi   +9 more
doaj   +1 more source

Effect of Corporate Governance Mechanisms on the Companies' Performance of Initial Public Offering in Tehran Stock Exchange [PDF]

مطالعات تجربی حسابداری مالی, 2016
Diffusion of corporate governance mechanisms leads to stabilize the financial markets, and economic growth and helps to companies to have a proper implementation of corporate governance in competition.
Ali Saghafi, Abdol Hossein Talebi Najafabadi   +1 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Epidemiology of Diagnosed Age-related Macular Degeneration in Germany: An Evaluation of the Prevalence Using AOK PLUS Claims Data

Ophthalmology and Therapy
Introduction Epidemiologic data on age-related macular degeneration (AMD) are mainly based on cohort studies, including both diagnosed and undiagnosed cases.
Alexander K. Schuster, Lilia Leisle, Nils Picker, Hanne Bubendorfer-Vorwerk, Philip Lewis, Philipp Hahn, Jürgen Wasem, Robert P. Finger   +7 more
doaj   +1 more source