Results 131 to 140 of about 5,851,986 (314)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Comparative Analysis of PSA Density and an MRI-Based Predictive Model to Improve the Selection of Candidates for Prostate Biopsy [PDF]

, 2022
Juan Moróte, Ángel Borque‐Fernando, Marina Triquell, A. Celma, Lucas Regis, Richard Mast, Inés M. de Torres, María Eugenia Semidey, J.M. Abascal Junquera, Pol Servián, Anna Santamaría, Jacques Planas, Luis Esteban, Enrique Trilla   +13 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Comparative analysis of environmental fragility by applying three models

, 2006
Christiane Spröl, Jurandyr Luciano Sanches Ross   +1 more
openalex   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Association of specific microbiota taxa in the amniotic fluid at birth with severe acute and longer-term outcomes of very preterm infants: a prospective observational study

BMC Medicine
Background Dysbiotic microbial colonization predisposes to severe outcomes of prematurity, including mortality and severe morbidities like necrotizing enterocolitis (NEC), late-onset infection (LOI) and bronchopulmonary dysplasia (BPD).
Birte Staude, Silvia Gschwendtner, Tina Frodermann, Frank Oehmke, Thomas Kohl, Susanne Walch, Michael Schloter, Harald Ehrhardt   +7 more
doaj   +1 more source

The cost of post-abortion care in developing countries: a comparative analysis of four studies [PDF]

, 2016
Michael Vlassoff, Susheela Singh, Tsuyoshi Onda   +2 more
openalex   +1 more source

Comparative analysis of diagnostic methods for the detection of Cryptococcus neoformans meningitis

, 2023
Kátia Cristina Dantas, Roseli Santos de Freitas, Suzete Cleusa Ferreira Spina Lombardi, Alfredo Mendroni Júnior, Marcos Silva, Paulo Ricardo Criado, Vera Lúcia Teixeira de Freitas, Terezinha Morato Bastos de Almeida   +7 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source