Results 131 to 140 of about 24,814,063 (309)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Neither Here nor There: The (Non-)Geographical Futures of Comparative Literature [PDF]
, 2014 The introduction to the special issue "(Non-)Geographical Futures of Comparative Literature", part of a joint project between CRCL/RCLC and Peking University\u27s Journal of Comparative Literature and World ...
Hui, Zhang, Fried, Daniel
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Comparative literature in an age of Globalization: Une réponse
, 2011 Comparative literature in an age of Globalization: Une ...
DE HUENEN, ROLAND
core
Comparative Literature in Canada: A Testimony from Below [PDF]
, 2014 A personal account of Valente\u27s "academic trajectory from Brazil to Canada, [which] asks to be understood as an analogy of the current status of Comparative Canadian Literature.
Valente, Andrea C.
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Comparative literature in an age of Globalization: A Review
, 2011 Comparative literature in an age of Globalization: A ...
RIGNEY, ANN
core