Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A data-driven comparative analysis on citation intents across scientific disciplines. [PDF]
Phan TA, Nam S, Jung JJ.
europepmc +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Factor selection in configurational comparative analysis - guidance for implementation researchers. [PDF]
Caci L, Blum K, Clack L, Albers B.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Botswana’s revealed comparative advantage [PDF]
Analysis of Botswana’s competitiveness in world trade has been presented based on indices of revealed comparative advantage (RCA) calculated for the period 1999 and 2004.
Makochekanwa, Albert
core
Karyotypic diversity in the Gobiidae: A comparative analysis of two Atlantic species. [PDF]
de Lima-Filho PA +3 more
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Microbiomes at the heart of sustainable agri-food systems and global health
Michael Schloter +2 more
doaj +1 more source
Comparative Analysis of the Immune Profiles of Women and Men With Hepatocellular Carcinoma. [PDF]
Macek Jilkova Z +8 more
europepmc +1 more source

