Results 111 to 120 of about 1,657,556 (272)

Guidance for unbiased predictive information for healthcare decision-making and equity (GUIDE): considerations when race may be a prognostic factor

npj Digital Medicine
Clinical prediction models (CPMs) are tools that compute the risk of an outcome given a set of patient characteristics and are routinely used to inform patients, guide treatment decision-making, and resource allocation. Although much hope has been placed
Keren Ladin, John Cuddeback, O. Kenrik Duru, Sharad Goel, William Harvey, Jinny G. Park, Jessica K. Paulus, Joyce Sackey, Richard Sharp, Ewout Steyerberg, Berk Ustun, David van Klaveren, Saul N. Weingart, David M. Kent   +13 more
doaj   +1 more source

Frequency and outcomes of treatment dose escalation with biologics in moderate-to-severe psoriasis: a Swedish register study

Journal of Dermatological Treatment
Background The advent of biosimilars may increase the frequency of dose escalation with biologics in psoriasis.Objective To explore the frequency and outcomes of dose escalation with adalimumab etanercept, and ustekinumab.Methods Data were extracted from
Axel Svedbom, Christina Wennerström, Fredrik Hjelm, Anna Tjärnlund, Mona Ståhle   +4 more
doaj   +1 more source

Comparative Effectiveness Research in Oncology [PDF]

The Oncologist, 2013
Learning Objectives Describe methods for assessing comparative effectiveness in the absence of data from high-quality randomized, controlled trials. Outline the criteria that should be applied to systematic reviews in order to use them for comparative effectiveness research.
openaire   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

User centred evaluation of an automatically constructed hyper-textbook [PDF]

, 2001
As hypertext systems become widely available and their popularity increases, attention has turned to converting existing textual documents into hypertextual form. An important issue in this area is the fully automatic production of hypertext for learning,
Crestani, F., Ntioudis, S.
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Approaches to Evaluate the Effectiveness of the Institutions of Innovative Environment [PDF]

, 2012
Purpose of the research: to study the problem of evaluating the effectiveness of innovative environment institutions, and to define the possible approaches to build a methodology for assessing the effectiveness.
Islamutdinov, Vadim
core  

Joint Regression and Ranking for Image Enhancement

, 2017
Research on automated image enhancement has gained momentum in recent years, partially due to the need for easy-to-use tools for enhancing pictures captured by ubiquitous cameras on mobile devices.
Chandakkar, Parag S., Li, Baoxin
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source