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Comparative Genomic Hybridization
2003Comparative genomic hybridization (CGH) is a molecular cytogenetic technique used to screen the entire genome for gains and losses of genetic material (1). It is being used increasingly in the study of cancer genetics to identify genes important in the initiation, progression, and, of particular relevance here, metastasis of tumors (2-4).One of the ...
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Comparative Genomic Hybridization Technique
2003Screening for chromosomal changes in solid tumors was long hindered by methodological problems encountered in standard cytogenetic analysis. Comparative genomic hybridization (CGH), a technique that emerged in 1992 (1) has proved to be a powerful tool for molecular cytogenetic analysis of neoplasms.
W E, El-Rifai, S, Knuutila
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Comparative genomic hybridization in ganglioneuroblastomas
Cancer Genetics and Cytogenetics, 2002The ganglioneuroblastoma are rare lesions with widespread neuronal differentiation that have been classified as intermediate stages between neuroblastoma and ganglioneuroma. To identify overall chromosome aberrations in ganglioneuroblastoma, we performed comparative genomic hybridization.
Toraman A.D. +4 more
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Oligonucleotide Array Comparative Genomic Hybridization
2007The array CGH technique (array comparative genome hybridization) has been developed to detect chromosomal copy number changes on a genome-wide and/or high-resolution scale. Here, we present validated protocols using in-house spotted oligonucleotide libraries for array CGH.
Van Den Ijssel, Paul, Ylstra, Bauke
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Comparative Genomic Hybridization: Practical Guidelines
Diagnostic Molecular Pathology, 2002Comparative genomic hybridization (CGH) is a technique used to identify copy number changes throughout a genome. Until now, hundreds of CGH studies have been published reporting chromosomal imbalances in a large variety of human neoplasms. Additionally, technical improvements of specific steps in a CGH experiment and reviews on the technique have ...
Jeuken, J.W.M. +2 more
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Comparative Genomic Hybridization
2002Comparative genomic hybridization (CGH) allows the entire genome of an organism to be scanned for relative changes in DNA copy number (copy number aberrations) (1–3) in a single experiment. Standard CGH can detect aneuploidies, deletions, and unbalanced translocations at a resolution of 5–10 megabases.
Burt G. Feuerstein +3 more
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Comparative genomic hybridization: Uses and limitations
Seminars in Hematology, 2000Comparative genomic hybridization (CGH) has contributed significantly to the current knowledge of genomic alterations in hematologic malignancies. Characteristic patterns of genomic imbalances not only have confirmed recent classification schemes in non-Hodgkin's lymphoma, but they provide a basis for the successful identification of genes with ...
P, Lichter, S, Joos, M, Bentz, S, Lampel
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Comparative genomic hybridization analysis of hepatoblastomas
Genes, Chromosomes and Cancer, 2000Prior cytogenetic analyses of hepatoblastomas have shown the most common recurring abnormalities to be trisomy for chromosomes 2 and 20, and a recurrent translocation involving chromosomes 1 and 4 identified in a minority of cases. Four cases have shown double minute chromosomes, which provide cytogenetic evidence for gene amplification, although no ...
J, Hu +3 more
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Comparative genomic hybridization analysis of craniopharyngiomas
Journal of Neurosurgery, 2003Object. Craniopharyngioma is the most common childhood brain tumor and is thought to arise from embryonic remnants of the Rathke pouch. Some craniopharyngiomas are monoclonal in origin and hence presumably harbor somatic genetic alterations, although the precise molecular mechanisms involved in craniopharyngioma development are unknown.
Shlomit, Rienstein +5 more
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Comparative Genomic Hybridization on BAC Arrays
2009Alterations in genomic DNA are a key feature of many constitutional disorders and cancer. The discovery of the underlying regions of gene dosage has thus been essential in dissecting complex disease phenotypes and identifying targets for therapeutic intervention and diagnostic testing.
Bradley P, Coe +3 more
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