Results 271 to 280 of about 88,145 (306)

Comparative Genomic Hybridization

2002
Comparative genomic hybridization (CGH) allows the entire genome of an organism to be scanned for relative changes in DNA copy number (copy number aberrations) (1–3) in a single experiment. Standard CGH can detect aneuploidies, deletions, and unbalanced translocations at a resolution of 5–10 megabases.
Burt G. Feuerstein, Yuichi Hirose, Malgorzata Pellarin, Gregg Magrane   +3 more
openaire   +1 more source

Comparative Genomic Hybridization on BAC Arrays

2009
Alterations in genomic DNA are a key feature of many constitutional disorders and cancer. The discovery of the underlying regions of gene dosage has thus been essential in dissecting complex disease phenotypes and identifying targets for therapeutic intervention and diagnostic testing.
Bradley P, Coe, William W, Lockwood, Raj, Chari, Wan L, Lam   +3 more
openaire   +2 more sources

Comparative genomic hybridization and prenatal diagnosis

Current Opinion in Obstetrics & Gynecology, 2006
Microarray-based comparative genomic hybridization (array-CGH) which detects aneuploidies and submicroscopic deletions and duplications in one assay is now offered for genetic diagnosis in children and adults. Its application to prenatal diagnosis is still limited, but very promising.
Ignatia B, Van den Veyver, Arthur L, Beaudet   +1 more
openaire   +2 more sources

In Situ Hybridization and Comparative Genomic Hybridization

1997
Quantitative and structural aberrations in the genomic content of malignancies or premalignant lesions are in many cases correlated with the prognosis of the disease. Since such genetic changes are central to the initiation and progression of neoplasms, techniques have been developed for their detection and characterization.
Anton H. N. Hopman, Christina E. M. Voorter, Ernst J. M. Speel, Frans C. S. Ramaekers   +3 more
openaire   +1 more source

Comparative Genomic Hybridization on Single Cells

2007
Comparative genomic hybridization (CGH) is a molecular cytogenetic technique developed for the analysis of chromosome imbalance in tumors and constitutional chromosome abnormalities. It is based on the analysis of genomic DNA and has the advantage over conventional karyotyping in that it does not require that metaphase chromosomes be obtained from the ...
Lucille, Voullaire, Leeanda, Wilton
openaire   +2 more sources

Comparative Genomic Hybridization of Wilms’ tumor

2013
Cytogenetic analysis of solid tumors including Wilms' tumor is challenging due to poor chromosome morphology, complexity of abnormalities, and to the possibility of stromal cell overgrowth in tissue culture. Molecular cytogenetic techniques such as chromosomal comparative genomic hybridization (CGH) have improved the diagnosis of chromosomal ...
Shahrad Rod, Rassekh, Evica, Rajcan-Separovic   +1 more
openaire   +2 more sources

A Hybrid Computational Grid Architecture for Comparative Genomics

IEEE Transactions on Information Technology in Biomedicine, 2008
Comparative genomics provides a powerful tool for studying evolutionary changes among organisms, helping to identify genes that are conserved among species, as well as genes that give each organism its unique characteristics. However, the huge datasets involved makes this approach impractical on traditional computer architectures leading to ...
Aarti Singh, Chen Chen, Weiguo Liu, Wayne P. Mitchell, Bertil Schmidt   +4 more
openaire   +2 more sources

Comparative genomic hybridization for cytogenetic evaluation of stillbirth

Obstetrics & Gynecology, 2000
To ascertain the feasibility and reliability of comparative genomic hybridization for cytogenetic evaluation of macerated stillbirths.We examined ten stillborn fetuses above 15 weeks' gestation whose karyotypes were unknown because of tissue culture failure. Sixteen fetuses that were successfully karyotyped using prenatal or postnatal tissues were also
Page - Christiaens, G.C.M.L., Vissers, J., Poddighe, P.J., de Pater, J.M.   +3 more
openaire   +3 more sources

Comparative genomic hybridization analysis of Wilms tumors

Cytogenetics and Cell Genetics, 1996
In this study we have applied the technique of comparative genomic hybridization (CGH) to a large series of sporadic Wilms tumors, including six samples of the associated nephroblastomatosis. The data obtained were compared with the findings of molecular studies carried out on the same material.
Steenman, M., Redeker, B., de Meulemeester, M., Wiesmeijer, K., Voûte, P. A., Westerveld, A., Slater, R., Mannens, M.   +7 more
openaire   +2 more sources

Array Comparative Genomic Hybridization in Osteosarcoma

2013
Osteosarcoma, the most frequent primary bone tumor, is a malignant mesenchymal sarcoma with a peak incidence in young children and adolescents. Left untreated, it progresses relentlessly to local and systemic disease, ultimately leading to death within months.
Bekim, Sadikovic, Paul C, Park, Shamini, Selvarajah, Maria, Zielenska   +3 more
openaire   +2 more sources