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Comparative Genomic Hybridization
Current Protocols in Cell Biology, 2004AbstractComparative genomic hybridization (CGH) is a screening method based on fluorescence in situ hybridization (FISH). In contrast to conventional FISH, the metaphase target is derived from a normal peripheral blood lymphocyte culture. This target is hybridized to the test or tumor DNA, which is labeled/detected by one fluorochrome (i.e., green ...
Jane, Bayani, Jeremy A, Squire
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Genome screening by comparative genomic hybridization
Trends in Genetics, 1997Comparative genomic hybridization (CGH) provides a molecular cytogenetic approach for genome-wide scanning of differences in DNA sequence copy number. The technique is now attracting wide-spread interest, especially among cancer researchers. The rapidly expanding database of CGH publications already covers about 1500 tumors and is beginning to reveal ...
F, Forozan +4 more
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Comparative Genomic Hybridization
2003Comparative genomic hybridization (CGH) is a molecular cytogenetic technique used to screen the entire genome for gains and losses of genetic material (1). It is being used increasingly in the study of cancer genetics to identify genes important in the initiation, progression, and, of particular relevance here, metastasis of tumors (2-4).One of the ...
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Comparative genomic hybridization analysis of hepatoblastomas
Genes, Chromosomes and Cancer, 2000Prior cytogenetic analyses of hepatoblastomas have shown the most common recurring abnormalities to be trisomy for chromosomes 2 and 20, and a recurrent translocation involving chromosomes 1 and 4 identified in a minority of cases. Four cases have shown double minute chromosomes, which provide cytogenetic evidence for gene amplification, although no ...
J, Hu +3 more
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Oligonucleotide Array Comparative Genomic Hybridization
2007The array CGH technique (array comparative genome hybridization) has been developed to detect chromosomal copy number changes on a genome-wide and/or high-resolution scale. Here, we present validated protocols using in-house spotted oligonucleotide libraries for array CGH.
Van Den Ijssel, Paul, Ylstra, Bauke
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Comparative genomic hybridization: Uses and limitations
Seminars in Hematology, 2000Comparative genomic hybridization (CGH) has contributed significantly to the current knowledge of genomic alterations in hematologic malignancies. Characteristic patterns of genomic imbalances not only have confirmed recent classification schemes in non-Hodgkin's lymphoma, but they provide a basis for the successful identification of genes with ...
P, Lichter, S, Joos, M, Bentz, S, Lampel
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Fluorescence In Situ Hybridization and Comparative Genomic Hybridization
2006This chapter discusses the complementary methodologies of fluorescence in situ hybridization and comparative genomic hybridization. Fluorescence in situ hybridization uses fluorescently labeled DNA probes (whole chromosomes, centromere, or locus-specific sequences) to visualize complementary DNA sequences in the target DNA (metaphase chromosomes or ...
Patricia, Gorman, Rebecca, Roylance
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Comparative Genomic Hybridization: Practical Guidelines
Diagnostic Molecular Pathology, 2002Comparative genomic hybridization (CGH) is a technique used to identify copy number changes throughout a genome. Until now, hundreds of CGH studies have been published reporting chromosomal imbalances in a large variety of human neoplasms. Additionally, technical improvements of specific steps in a CGH experiment and reviews on the technique have ...
Jeuken, J.W.M. +2 more
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Comparative genomic hybridization analysis of craniopharyngiomas
Journal of Neurosurgery, 2003Object. Craniopharyngioma is the most common childhood brain tumor and is thought to arise from embryonic remnants of the Rathke pouch. Some craniopharyngiomas are monoclonal in origin and hence presumably harbor somatic genetic alterations, although the precise molecular mechanisms involved in craniopharyngioma development are unknown.
Shlomit, Rienstein +5 more
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Comparative genomic hybridization in epithelioid sarcoma
British Journal of Dermatology, 2004Epithelioid sarcoma is a rare mesenchymal neoplasm of unknown histogenesis. Data on genome-wide surveys for chromosomal aberrations in epithelioid sarcoma are limited.To investigate genetic aberrations in epithelioid sarcoma.We analysed seven cases of epithelioid sarcoma (classic type, three cases and proximal type, four cases) by comparative genomic ...
M-W, Lee +6 more
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