Results 231 to 240 of about 2,755,876 (359)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Comparative genomics of Aspergillus nidulans and section Nidulantes. [PDF]

Curr Res Microb Sci
Theobald S, Vesth T, Nybo JL, Frisvad JC, Kjærbølling I, Mondo S, LaButti K, Haridas S, Riley R, Kuo AA, Salamov AA, Pangilinan J, Lipzen A, Koriabine M, Yan M, Barry K, Clum A, Lyhne EK, Drula E, Wiebenga A, Müller A, Lubbers RJM, Kun RS, Dos Santos Gomes AC, Mäkelä MR, Henrissat B, Simmons BA, Magnuson JK, Hoof JB, Mortensen UH, Dyer PS, Momany M, Larsen TO, Grigoriev IV, Baker SE, de Vries RP, Andersen MR.   +36 more
europepmc   +1 more source

The use of real‐time quantitative polymerase chain reaction and comparative genomic hybridization to identify amplification of the REL gene in follicular lymphoma [PDF]

, 2000
Lindsey K. Goff, Michael Neat, Charles Crawley, Louise Jones, Emma Jones, Tim Lister, Rajnish K. Gupta   +6 more
openalex   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Comparative genomics and phylogenetic analysis of mitochondrial genomes of Neocinnamomum. [PDF]

BMC Plant Biol
Zhu W, Zhang D, Xu W, Gan Y, Huang J, Liu Y, Tan Y, Song Y, Xin P.   +8 more
europepmc   +1 more source

Genetic changes in breast cancer detected by comparative genomic hybridisation

, 2000
Ruth L. Loveday, John Greenman, Deborah L. Simcox, Valerie Speirs, Philip Drew, John R.T. Monson, Michael J. Kerin   +6 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Comparative genomics uncovers evolutionary drivers of locust migratory adaptation. [PDF]

BMC Genomics
Dong S, Li X, Liu Q, Zhu T, Tian A, Chen N, Tu X, Ban L.   +7 more
europepmc   +1 more source

DNA Ploidy and Chromosomal Imbalances in Invasive Ductal Breast Cancer. A Comparative Study of DNA Image Cytometry and Comparative Genomic Hybridization (CGH) [PDF]

, 2000
Katrin Friedrich, Jens Scheithauer, V. Dimmer, W. Meyer, F Theissig, G. Haroske, Klaus Dietmar Kunze   +6 more
openalex   +1 more source

Insect pathogenicity in plant-beneficial pseudomonads: phylogenetic distribution and comparative genomics

The ISME Journal, 2016
P. Flury, Nora Aellen, B. Ruffner, Maria Péchy-Tarr, S. Fataar, Z. Metla, Ana Dominguez-Ferreras, G. Bloemberg, J. Frey, A. Goesmann, J. Raaijmakers, B. Duffy, M. Höfte, J. Blom, T. H. Smits, C. Keel, M. Maurhofer   +16 more
semanticscholar   +1 more source