Results 231 to 240 of about 449,093 (327)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Comparative genomics of Bacillus velezensis and Bacillus subtilis reveals distinction and evolution of lipopeptide antimicrobial gene clusters. [PDF]

BMC Genomics
Zeng Q, Zhao Y, Zhuang L, Jiang W, Wang L, Zhang J, Wang L, Guo H, Li Y, Wang Z, Li Y, Wang Q.   +11 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Comparative Genomics of Human- and Wastewater-Derived CPE Isolates in The Netherlands Reveals Shared and Complementary Characteristics. [PDF]

Microorganisms
Blaak H, Witteveen S, de Haan A, van Santen-Verheuvel MG, Kemper MA, de Roda Husman AM, Hendrickx APA, Schmitt H, The Dutch Cpe Surveillance Study Group.   +8 more
europepmc   +1 more source

Whole-genome sequencing and comparative genomic analysis of Irpex lacteus isolated from the female reproductive tract

Yixuan Wang, Shujuan Zhang, Shi-Ling Han, Xiaomeng Ge, Shenghan Gao, Qianhui Zhu, Yadong Liu, Songnian Hu, Ziwen Jiang, Yinmei Dai, Lei Cai, Yu Fu   +11 more
openalex   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Decoding the genetic drivers of marine bacterial blooms through comparative genomics. [PDF]

Microbiome
Rey-Velasco X, Auladell A, Deulofeu-Capo O, Lundin D, Pinhassi J, Ferrera I, Sánchez O, Gasol JM.   +7 more
europepmc   +1 more source

Additional file 3 of Comparative genomic and phenotypic analysis of Escherichia coli ST1193 and ST131 from urinary and bloodstream infections: insights into resistance, virulence, and divergent strategies

Qian Zeng, Su Wang, Shuzhen Xiao, Huifang Liu, Feifei Gu, Lizhong Han, xiaofei jiang   +6 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Gap-free comparative genomics uncover virulence factors for Fusarium wilt of watermelons. [PDF]

PLoS Pathog
Ayhan DH, Wang H, Zhang L, Wang G, Yi S, Meng D, Xue L, Geng X, Kong Z, Wang X, Wang L, Yang Q, Wang X, Deng Y, Zhang X, Guo L.   +15 more
europepmc   +1 more source