Results 221 to 230 of about 3,218,020 (355)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

FetchM: streamlining genome and metadata integration for bacterial comparative genomics. [PDF]

Bioinform Adv
Anik TA, Kjær Mackie Jensen P, Begum A.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Editorial for Special Issue "Functional Genomics and Comparative Genomics Analysis in Plants, 3rd Edition". [PDF]

Curr Issues Mol Biol
Li Z, Su R, Jin Q, Zou Q.
europepmc   +1 more source

Comparative genomics sheds light on niche differentiation and the evolutionary history of comammox Nitrospira

The ISME Journal, 2018
Alejandro Palomo, A. Pedersen, Jane E. Fowler, A. Dechesne, Thomas Sicheritz-Pontén, B. Smets   +5 more
semanticscholar   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Applications of Bayesian methods in Genomics and Comparative Genomics

Applications of Bayesian methods in Genomics and Comparative Genomics. Bayesian statistics provides a unified and versatile approach to problems of data analysis, inference and hypothesis testing.

core  

Author Correction: Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist

Nature Communications, 2021
Dayana E. Salas-Leiva, Eelco C. Tromer, Bruce A. Curtis, Jon Jerlström-Hultqvist, Martin Kolisko, Zhenzhen Yi, Joan S. Salas-Leiva, Lucie Gallot-Lavallée, Shelby K. Williams, Geert J. P. L. Kops, John M. Archibald, Alastair G. B. Simpson, Andrew J. Roger   +12 more
doaj   +1 more source

Comparative genomics reveal signatures of ecological specialization in the striped ambrosia beetle Trypodendron lineatum. [PDF]

BMC Genomics
Montes-Ortiz Z, Powell D, Vogel H, Löfstedt C, Andersson MN.   +4 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source