Results 241 to 250 of about 3,218,020 (355)

Comparative genomics of human brain and immune gene preservation across species. [PDF]

PLoS One
Liang X, Teich AF, Heath LS.
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Comparative Genomics Provide Insight Into the Evolution of European Aphanomyces euteiches Strains. [PDF]

Genome Biol Evol
Kälin C, Piombo E, Manyara D, Dubusc S, Dubey M, Karlsson M.   +5 more
europepmc   +1 more source

A parts list for fungal cellulosomes revealed by comparative genomics

Nature Microbiology, 2017
Charles H. Haitjema, Sean P. Gilmore, J. Henske, Kevin V. Solomon, R. de Groot, A. Kuo, S. Mondo, A. Salamov, K. Labutti, Zhiying Zhao, Jennifer Chiniquy, Kerrie W. Barry, H. Brewer, S. Purvine, A. Wright, Matthieu Hainaut, B. Boxma, T. V. van Alen, J. Hackstein, B. Henrissat, S. Baker, I. Grigoriev, M. O’Malley   +22 more
semanticscholar   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Unveiling the genomic secrets of <i>Micrococcus luteus</i> through a comprehensive comparative genomics approach. [PDF]

Front Genet
Kabiraj A, Khan D, Shaw R, Ghorui M, Bandopadhyay R.   +4 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Pseudogenization of the chaperonin system in '<i>Candidatus</i> Phytoplasma pruni' revealed by genome sequencing and comparative genomics. [PDF]

Microb Genom
Pellegrinetti TA, Hammond C, Pérez-López E, Muirhead K, Bennypaul H, Sanderson D, Dumonceaux TJ.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source