Results 241 to 250 of about 2,755,876 (359)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Identification of candidate host-specificity genes in Exserohilum turcicum using comparative genomics and transcriptomics. [PDF]

G3 (Bethesda)
Krone MJ, Adhikari P, Singh P, Jamann TM, Mideros SX.   +4 more
europepmc   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Comparative genomics of the highly halophilic Haloferacaceae. [PDF]

Sci Rep
Griffiths DB, Tiwari RP, Murphy DV, Scott C.   +3 more
europepmc   +1 more source

Comparative genomics of biotechnologically important yeasts

Proceedings of the National Academy of Sciences of the United States of America, 2016
R. Riley, S. Haridas, K. H. Wolfe, Mariana R. Lopes, Chris Todd Hittinger, M. Göker, A. Salamov, Jennifer H. Wisecaver, T. M. Long, C. Calvey, A. Aerts, K. Barry, C. Choi, Alicia Clum, Aisling Y. Coughlan, Shweta Deshpande, Alexander P Douglass, S. Hanson, H. Klenk, K. Labutti, A. Lapidus, E. Lindquist, A. Lipzen, Jan P. Meier-Kolthoff, R. Ohm, Robert Otillar, Jasmyn Pangilinan, Yi Peng, A. Rokas, C. Rosa, Carmen Scheuner, A. Sibirny, J. Slot, J. B. Stielow, Hui Sun, C. Kurtzman, M. Blackwell, I. Grigoriev, T. Jeffries, C. Somerville   +39 more
semanticscholar   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Comparative genomics and evolutionary insights into zeaxanthin biosynthesis in two novel Flavobacterium species. [PDF]

BMC Microbiol
Zhuo Y, Jin CZ, Lee CS, Shin KS, Lee HG.
europepmc   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Comparative genomics provides insights into the biogeographic and biochemical diversity of meliaceous species. [PDF]

Nat Commun
Liu J, Wang Z, Su X, Leng L, Liu J, Zhang F, Chen S, Zhang Y, Wang C.   +8 more
europepmc   +1 more source

Comparative genomics in development [PDF]

, 2000
Robert Frederickson
openalex   +1 more source