Results 51 to 60 of about 173,818 (165)

Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping

Disease Models & Mechanisms, 2016
In the decade following publication of the draft genome sequence of the domestic dog, extraordinary advances with application to several fields have been credited to the canine genetic system.
Dayna L. Dreger, Maud Rimbault, Brian W. Davis, Adrienne Bhatnagar, Heidi G. Parker, Elaine A. Ostrander   +5 more
doaj   +1 more source

Paleo‐metagenomics of North American fossil packrat middens: Past biodiversity revealed by ancient DNA

Ecology and Evolution, 2020
Fossil rodent middens are powerful tools in paleoecology. In arid parts of western North America, packrat (Neotoma spp.) middens preserve plant and animal remains for tens of thousands of years.
Grace Moore, Michael Tessler, Seth W. Cunningham, Julio Betancourt, Robert Harbert   +4 more
doaj   +1 more source

Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders

BMC Evolutionary Biology, 2020
Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder. PD associated human UCHL1 (Ubiquitin C-terminal hydrolase L1) gene belongs to the family of deubiquitinases and is known to be highly expressed in neurons (1–2% in ...
Muhammad Saqib Nawaz, Razia Asghar, Nashaiman Pervaiz, Shahid Ali, Irfan Hussain, Peiqi Xing, Yiming Bao, Amir Ali Abbasi   +7 more
doaj   +1 more source

Population genetic structure and habitat connectivity for jaguar (Panthera onca) conservation in Central Belize

BMC Genetics, 2019
Background Connectivity among jaguar (Panthera onca) populations will ensure natural gene flow and the long-term survival of the species throughout its range.
Angelica Menchaca, Natalia A. Rossi, Jeremy Froidevaux, Isabela Dias-Freedman, Anthony Caragiulo, Claudia Wultsch, Bart Harmsen, Rebecca Foster, J. Antonio de la Torre, Rodrigo A. Medellin, Salisa Rabinowitz, George Amato   +11 more
doaj   +1 more source

Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene

BMC Evolutionary Biology, 2019
Background Frizzled family members belong to G-protein coupled receptors and encode proteins accountable for cell signal transduction, cell proliferation and cell death. Members of Frizzled receptor family are considered to have critical roles in causing
Suman Seemab, Nashaiman Pervaiz, Rabail Zehra, Saneela Anwar, Yiming Bao, Amir Ali Abbasi   +5 more
doaj   +1 more source

Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius

Nature Communications, 2016
The common bedbug is a pest for humans, yet its molecular biology is poorly understood. Here, the authors sequence the common bedbug genome and profile gene expression across all life stages to show major changes in gene expression after feeding on human
Jeffrey A. Rosenfeld, Darryl Reeves, Mercer R. Brugler, Apurva Narechania, Sabrina Simon, Russell Durrett, Jonathan Foox, Kevin Shianna, Michael C. Schatz, Jorge Gandara, Ebrahim Afshinnekoo, Ernest T. Lam, Alex R. Hastie, Saki Chan, Han Cao, Michael Saghbini, Alex Kentsis, Paul J. Planet, Vladyslav Kholodovych, Michael Tessler, Richard Baker, Rob DeSalle, Louis N. Sorkin, Sergios-Orestis Kolokotronis, Mark E. Siddall, George Amato, Christopher E. Mason   +26 more
doaj   +1 more source

Chromosome-level assembly of the horseshoe crab genome provides insights into its genome evolution

Nature Communications, 2020
Horseshoe crabs have been morphologically stable across evolutionary time. Here, the authors generate a chromosome-level assembly for the mangrove horseshoe crab, with implications for innate immunity, and challenging assumptions about the role of genome
Prashant Shingate, Vydianathan Ravi, Aravind Prasad, Boon-Hui Tay, Kritika M. Garg, Balaji Chattopadhyay, Laura-Marie Yap, Frank E. Rheindt, Byrappa Venkatesh   +8 more
doaj   +1 more source

Seqrutinator: scrutiny of large protein superfamily sequence datasets for the identification and elimination of non-functional homologues

Genome Biology
Seqrutinator is an objective, flexible pipeline that removes sequences with sequencing and/or gene model errors and sequences from pseudogenes from complex, eukaryotic protein superfamilies.
Agustín Amalfitano, Nicolás Stocchi, Hugo Marcelo Atencio, Fernando Villarreal, Arjen ten Have   +4 more
doaj   +1 more source

A web-based, patient driven registry for Angelman syndrome: the global Angelman syndrome registry

Orphanet Journal of Rare Diseases, 2017
Angelman syndrome (AS) is a rare neurodevelopmental disorder that is characterised by severe global developmental delays, ataxia, loss of speech, epilepsy, sleep disorders, and a happy disposition.
Kathryn R. Napier, Megan Tones, Chloe Simons, Helen Heussler, Adam A. Hunter, Meagan Cross, Matthew I. Bellgard   +6 more
doaj   +1 more source

The animal in the genome: comparative genomics and evolution [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2008
Comparisons between completely sequenced metazoan genomes have generally emphasized how similar their encoded protein content is, even when the comparison is between phyla. Given the manifest differences between phyla and, in particular, intuitive notions that some animals are more complex than others, this creates something of a ...
openaire   +3 more sources