Results 111 to 120 of about 3,124,272 (306)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Social Citizenship and Institution Building: EU-Enlargement and the Restructuring of Welfare States in East Central Europe, CES Germany & Europe Working Paper no. 01.2, April 2001 [PDF]
, 2001 With the EU-enlargement process well underway, this paper focuses on social citizenship as a conceptual frame for analyzing the restructuring of social institutions in applicant countries in East Central Europe. So far, comparative welfare state analysis
Lemke, Christiane.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Factors influencing treatment adherence in hypertension and HIV management in South Africa: A comparative literature review. [PDF]
S Afr Fam Pract (2004), 2022 Enslin D, Mallya P.
europepmc +1 more source
On Comparative Literature [PDF]
International Journal of Literature and Arts, 2016 This study focuses on issues such as what comparative literature is or not, how it is perceived today, what its benefits are, what kinds of mistakes are made in theory and practice in comparisons of the texts. The term 'literature' has been scene of plentiful discussions from the Greek and Latin civilizations to our age.
openaire +1 more source
A Note on International Fiscal Policy Practices [PDF]
The paper proposes an overview of the literature in fiscal policies as well as a comparative assessment in an international context. A large section addresses the specific question of the European fiscal rule, namely the Stability and Growth Pact (SGP).
Thierry Warin
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Inherited Retinal Dystrophy in Southeastern United States: Characterization of South Carolina Patients and Comparative Literature Review. [PDF]
Genes (Basel), 2022 Griffith J +8 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source