Results 121 to 130 of about 3,124,272 (306)

And So The Judge Returns: Blood Meridian Workshop at the University of Warwick

open access: yesExchanges, 2016
Pulitzer Prize winning author Cormac McCarthy’s work has become required reading in literary criticism, and yet no syllabus appears to provision for the in-depth discussion his texts, particularly the 1985 novel, Blood Meridian: Or, the Evening Redness ...
Katja Laug
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

World Literatures, Comparative Literature, and Glocal Cosmopolitanism

open access: yesCLCWeb: Comparative Literature and Culture, 2013
In his article "World Literatures, Comparative Literature, and Glocal Cosmopolitanism" Paolo Bartoloni reflects on the topos of the crisis of literature and the humanities. An urge to question the status and the relevance of literature; to investigate the relation between literature and literary studies; and the location of literature
openaire   +4 more sources

On Essence and Masurement of Changes in Competitiveness of the Accession Countries. Critical Review of Literature [PDF]

open access: yes
Although competitiveness is a world very often used in literature it is seldom to be found in economic textbook which prefer the term comparative advantage much narrowly defining formula describing international specialization.
Anna Wziatek-Kubiak
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Recasting the Brahmin: Martin Wickramasinghe and the Epistemic Critique of Caste

open access: yesCaste
The dominant public perception is that caste is a matter of minor and diminishing significance in Sri Lanka, especially for the Sinhalese, who form the island’s ethnic majority.
Praveen Tilakaratne
doaj   +1 more source

On World Literatures, Comparative Literature, and (Comparative) Cultural Studies

open access: yesCLCWeb: Comparative Literature and Culture, 2013
In his article "On World Literatures, Comparative Literature, and (Comparative) Cultural Studies" Ning Wang argues that cultural studies is characterized by being opposed to (elite) literary studies not only because it points to popular or non-elite literature, but also because it challenges the discipline of comparative literature. On the other hand, (
openaire   +4 more sources

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