Results 131 to 140 of about 9,079,177 (311)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Literature, History, and Narrative: A New Historicist Reading of Yan Geling’s “Celestial Bath” [PDF]
, 2018 "The relationship between history and literature has long been a key element in literary studies: Marxism, old historicism, and new historicism all relate text to context, and comparative literature as a discipline has stressed literary history and ...
Guo, Rong
core
And So The Judge Returns: Blood Meridian Workshop at the University of Warwick
Exchanges, 2016 Pulitzer Prize winning author Cormac McCarthy’s work has become required reading in literary criticism, and yet no syllabus appears to provision for the in-depth discussion his texts, particularly the 1985 novel, Blood Meridian: Or, the Evening Redness ...
Katja Laug
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Two Questions about Categories in the Relationship of Chinese Literature to World Literature [PDF]
, 2014 "The independently-developed tradition of Chinese literature points to the necessity of constantly rethinking world genre boundaries. For example, spoken theatre is not a universal genre, but a specific Western form that has spread through imperialistic ...
Stenberg, Josh
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Towards a Globalectical Reading of Comparative Canadian Literature [PDF]
, 2014 Discusses the academic study of Canadian literature written in languages other than English and French: "We cannot speak of trans-Canadian literature and moving beyond the national borders until we have fully recognized what lies within our borders.
Sayed, Asma
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source