Results 151 to 160 of about 49,054,835 (307)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

In Class With Bertens & Co.: A Very Brief (Comparative, Critical, and Casual) Homage. Forum

open access: yes, 2011
In Class With Bertens & Co.: A Very Brief (Comparative, Critical, and Casual) Homage ...
RUTHNER, CLEMENS
core  

You and Me: Relational Ontologies in Canadian Comparative Literature [PDF]

open access: yes, 2014
"Insofar as Comparative Literature in Canada ostensibly provides a framework for critical and collaborative labour, it is also a crucial space for decolonization and the indigenization of university curricula and modes of research production ...
Parker, Lindsay R.
core  

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Modernity and Folklore from the Perspective of Comparative Literature: An Introduction

open access: yes, 2011
Modernity and Folklore from the Perspective of Comparative Literature: An ...
SHEN, LIYAN
core  

Review: The Promise and Premise of Creativity: Why Comparative Literature Matters [PDF]

open access: yes, 2013
Review article on Eugene Eoyang, The Promise and Premise of Creativity: Why Comparative Literature Matters (New York: Continuum International Publishing, 2012)
Sondrup, Steven P.
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

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