Results 1 to 10 of about 160,350 (117)

From comparative oncology to AI-enabled precision medicine: translational biomodels for triple-negative breast cancer [PDF]

Frontiers in Oncology
Triple-negative breast cancer (TNBC), defined by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression or amplification, comprises a biologically heterogeneous group of tumors with aggressive ...
Tiago Veiras Collares, Tiago Veiras Collares, Tiago Veiras Collares, Fabiana Kömmling Seixas, Fabiana Kömmling Seixas, Claudia Pessoa, Claudia Pessoa, Maria Lucia Zaidan Dagli, Maria Lucia Zaidan Dagli   +8 more
doaj   +2 more sources

Editorial: Comparative Oncology–Advances in Veterinary Molecular Oncology [PDF]

Frontiers in Veterinary Science, 2022
Kristina Meichner, Angela L. McCleary-Wheeler, Hiroyuki Mochizuki, Tracy Stokol   +3 more
doaj   +2 more sources

Editorial: Cancer in domestic, exotic and wild animals: new horizons in tumorigenesis, diagnosis, prognosis and therapeutics through comparative oncology [PDF]

Frontiers in Veterinary Science
Yasunaga Yoshikawa, Isabel Pires, Leonardo Leonardi   +2 more
doaj   +2 more sources

TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response

Cell Death and Disease, 2023
TP73 is expressed as multiple N- and C-terminal isoforms through two separate promoters or alternative splicing. While N-terminal p73 isoforms have been well studied, very little is known about p73 C-terminal isoforms.
Jin Zhang, Wenqiang Sun, Wensheng Yan, Xiangmudong Kong, Tong Shen, Kyra Laubach, Mingyi Chen, Xinbin Chen   +7 more
doaj   +1 more source

Impact of limb amputation and cisplatin chemotherapy on metastatic progression in mouse models of osteosarcoma

Scientific Reports, 2021
Development of animal models that accurately recapitulate human cancer is an ongoing challenge. This is particularly relevant in the study of osteosarcoma (OS), a highly malignant bone tumor diagnosed in approximately 1000 pediatric/adolescent patients ...
L. Ren, S. Huang, J. Beck, Amy K. LeBlanc   +3 more
doaj   +1 more source

Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

eLife, 2023
TP73, a member of the p53 family, is expressed as TAp73 and ΔNp73 along with multiple C-terminal isoforms (α−η). ΔNp73 is primarily expressed in neuronal cells and necessary for neuronal development.
Xiangmudong Kong, Wensheng Yan, Wenqiang Sun, Yanhong Zhang, Hee Jung Yang, Mingyi Chen, Hongwu Chen, Ralph W de Vere White, Jin Zhang, Xinbin Chen   +9 more
doaj   +1 more source

The RNA-binding protein RBM24 regulates lipid metabolism and SLC7A11 mRNA stability to modulate ferroptosis and inflammatory response

Frontiers in Cell and Developmental Biology, 2022
Lipids play a critical role in many cellular processes by serving as structural components of cell membranes or functioning as energy fuel and signaling molecules. The RNA-binding proteins RBM24 and RBM38 share an identical RNA-binding domain and thereby,
Jin Zhang, Xiangmudong Kong, Wenqiang Sun, Leyi Wang, Tong Shen, Mingyi Chen, Xinbin Chen   +6 more
doaj   +1 more source

Characterization of D-17 Canine Osteosarcoma Cell Line and Evaluation of Its Ability to Response to Infective Stressor Used as Alternative Anticancer Therapy

Animals, 2020
Osteosarcoma (OSA) is a rare cancer both in human and dog although the incidence rate in dogs is 27 times higher than in human. Many studies employed D-17 as cell line for in vitro test to evaluate conventional anticancer therapies; however, little is ...
Paola Modesto, Jordi Leonardo Castrillo Fernandez, Isabella Martini, Roberto Zoccola, Maria Concetta Pugliano, Chiara Grazia De Ciucis, Maria Goria, Angelo Ferrari, Elisabetta Razzuoli   +8 more
doaj   +1 more source

p73α1, an Isoform of the p73 Tumor Suppressor, Modulates Lipid Metabolism and Cancer Cell Growth via Stearoyl-CoA Desaturase-1

Cells, 2022
Altered lipid metabolism is a hallmark of cancer. p73, a p53 family member, regulates cellular processes and is expressed as multiple isoforms. However, the role of p73 in regulating lipid metabolism is not well-characterized.
Zachary Rabow, Kyra Laubach, Xiangmudong Kong, Tong Shen, Shakur Mohibi, Jin Zhang, Oliver Fiehn, Xinbin Chen   +7 more
doaj   +1 more source

A Pilot Study of Cancer-Induced Bone Pain Using Validated Owner Questionnaires, Serum N-Telopeptide Concentration, Kinetic Analysis, and PET/CT

Frontiers in Veterinary Science, 2021
Cancer-induced bone pain, despite its frequency and severity, is a poorly understood phenomenon in people and animals. Despite excitement regarding translational osteosarcoma studies, there is a lack of attention toward examining cancer pain in dogs.
Brian K. Flesner, Bryan T. Torres, Kyle D. Hutcheson, Hansjörg Rindt, Amy R. Zalcman, Charles A. Maitz   +5 more
doaj   +1 more source