Results 111 to 120 of about 1,667,677 (293)
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon +3 more
wiley +1 more source
ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo +2 more
wiley +1 more source
ABSTRACT Over the past century, the discovery of insulin transformed type 1 diabetes from a fatal disease into a manageable chronic condition, and the subsequent recognition of its autoimmune basis laid the foundation for screening and intervention before clinical onset.
Noriko Kodani
wiley +1 more source
GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani +8 more
wiley +1 more source
Zhuo Wang, N. Verma
semanticscholar +1 more source
A low‐cost handheld device for monitoring cutaneous photosensitivity
The cutaneous photosensitivity detection (CPD) device is a handheld contact‐based measurement device using 405 nm excitation and red fluorescence detection for monitoring skin phototoxicity risk after photodynamic therapy (PDT) procedures involving systemic aminolaevulinic acid (ALA) induced protoporphyrin IX (PpIX) photosensitization.
Md Asaduzzaman Rasel +4 more
wiley +1 more source
Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou +11 more
wiley +1 more source
Abstract High‐altitude exposure increases haemoglobin mass (Hbmass), a key determinant of arterial oxygen‐carrying capacity, but following descent this adaptation can regress toward baseline within 7 days. Long‐term heat acclimation has emerged as an alternative stimulus for Hbmass expansion; however, whether post‐altitude passive‐heat exposure can ...
Elliott J. Jenkins +12 more
wiley +1 more source
Abstract Figure Legend Endurance‐trained runners completed a 5‐week hot‐water‐immersion (HWI) intervention (≥40°C, 45 min, five sessions per week) and a training‐matched control period in a cross‐over design. HWI induced a 33 g increase in haemoglobin mass (Hbmass) and a 10 mL expansion in left‐ventricular end‐diastolic volume (LVEDV), resulting in a 2.
Elliott J. Jenkins +7 more
wiley +1 more source
Optokinetic stimulation modulates vestibular contribution to postural control
Abstract figure legend Healthy young adults completed repeated standing balance trials while receiving stochastic vestibular stimulation (SVS) with or without optokinetic visual motion. Vestibular contributions to postural control were quantified from the frequency‐domain coupling between SVS and mediolateral ground reaction forces using coherence and ...
Antonio S. Pierre +4 more
wiley +1 more source

