Results 31 to 40 of about 663,640 (272)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Invasion entire solutions in a time periodic Lotka-Volterra competition system with diffusion

Mathematical Biosciences and Engineering, 2017
This paper is concerned with invasion entire solutions of a monostable time periodic Lotka-Volterra competition-diffusion system. We first give the asymptotic behaviors of time periodic traveling wave solutions at infinity by a dynamical approach coupled
Li-Jun Du, Wan-Tong Li, Jia-Bing Wang
doaj   +1 more source

Existence and Multiplicity of Solutions for a Class of Particular Boundary Value Poisson Equations

Mathematics, 2022
In this paper, a special class of boundary value problems, −▵u=λuq+ur,inΩ,u>0, inΩ,n·∇u+g(u)u=0,on∂Ω, where ...
Songyue Yu, Baoqiang Yan
doaj   +1 more source

A comparison principle for convolution measures with applications [PDF]

Math. Proc. Camb. Phil. Soc. 169 (2020) 307-322, 2018
We establish the general form of a geometric comparison principle for $n$-fold convolutions of certain singular measures in $\mathbb{R}^d$ which holds for arbitrary $n$ and $d$. This translates into a pointwise inequality between the convolutions of projection measure on the paraboloid and a perturbation thereof, and we use it to establish a new sharp ...
arxiv   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Blow-up in a p-Laplacian mutualistic model based on graphs

AIMS Mathematics, 2023
In this paper, we study a $ p\, $-Laplacian ($ p > 2 $) reaction-diffusion system based on weighted graphs that is used to describe a network mutualistic model of population ecology.
Ling Zhou, Zuhan Liu
doaj   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

On necessary conditions for the Comparison Principle and the Sub and Supersolutions Method for the stationary Kirchhoff Equation [PDF]

Journal of Mathematical Physics (Vol.59, Issue 1) 011506 (2018), 2017
In this paper we propose a counterexample to the validity of the Comparison Principle and of the Sub and Supersolution Method for nonlocal problems like the stationary Kirchhoff Equation. This counterexample shows that in general smooth bounded domains in any dimension, these properties cannot hold true if the nonlinear nonlocal term $M(\|u\|^2)$ is ...
arxiv   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

On the Strong Comparison Principle for Degenerate Elliptic Problems with Convection [PDF]

arXiv, 2022
The weak and strong comparison principles, respectively, are investigated for quasi-linear elliptic boundary value problems with the $p$-Laplacian in one space dimension. We treat the degenerate case of $2 < p < \infty$ and allow also for the nontrivial convection velocity $b\colon [-1,1]\to \mathbb{R}$ in the underlying domain $(-1,1)$.
arxiv