Results 41 to 50 of about 663,640 (272)

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

Molecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang, Simone van de Weerd, Veerle Lammers, Sander van Hooff, Inge van den Berg, Saskia van den Bergh, Miriam Koopman, Jan N. IJzermans, Jeanine M. L. Roodhart, Jan Koster, Jan Paul Medema   +10 more
wiley   +1 more source

A singular ODE related to quasilinear elliptic equations

Electronic Journal of Differential Equations, 2000
We consider a quasilinear elliptic problem with the natural growth in the gradient. Existence, non-existence, uniqueness, and qualitative properties of positive solutions are obtained. We consider both weak and strong solutions.
Luka Korkut, Mervan Pasic, Darko Zubrinic   +2 more
doaj  

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

On the initial-boundary value problem for a nonlocal parabolic equation with nonlocal boundary condition

Журнал Белорусского государственного университета: Математика, информатика, 2018
We consider a nonlinear nonlocal parabolic equation ut = Δu + a(x,t)ur∫Ωup(y,t)dy - b(x,t)uq for (x,t) ∈ Ω × (0,+∞) with nonlinear nonlocal boundary condition u(x,t)|∂Ω × (0,+∞) = ∫Ωk(x,y,t)ul(y,t)dy and initial data u(x,0) = u0(x), x ∈ Ω, where r, p, q,
Alexander L. Gladkov, Tatiana V. Kavitova   +1 more
doaj  

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

An eigenvalue problem for the infinity-Laplacian

Electronic Journal of Differential Equations, 2013
In this work, we study an eigenvalue problem for the infinity-Laplacian on bounded domains. We prove the existence of the principal eigenvalue and a corresponding positive eigenfunction.
Tilak Bhattacharya, Leonardo Marazzi
doaj  

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Enhancing patient engagement in cancer research: a focus on patient‐centric approaches to scientific discovery

Molecular Oncology, EarlyView.
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda, Marina Reguero, Vanesa Abón, Marta Puyol   +3 more
wiley   +1 more source

A simple proof of a strong comparison principle for semicontinuous viscosity solutions of the prescribed mean curvature equation [PDF]

arXiv, 2018
A strong comparison principle for semicontinuous viscosity solutions of the prescribed mean curvature equation is considered. The difficulties of the problem come from the fact that this nonlinear equation is non-uniformly elliptic, does not depend on the value of unknown functions, depends on spatial variables and solutions are semicontinuous.
arxiv