Results 71 to 80 of about 5,620,148 (306)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Minimal wave speed of traveling wavefronts in delayed Belousov-Zhabotinskii model

Electronic Journal of Qualitative Theory of Differential Equations, 2012
This paper is concerned with the traveling wavefronts of Belousov-Zhabotinskii model with time delay. By constructing proper upper and lower solutions and applying the theory of asymptotic spreading, the minimal wave speed is obtained under the weaker ...
Shuxia Pan, Jie Liu
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Comparison principle for difference equations with variable-time impulses

, 2018
In this paper, a class of difference equations with variable-time impulses is considered. By applying comparison principle, we shall show that difference equations with variable-time impulse can be reduced to the corresponding difference equations with ...
Chuandong Li, Hongfei Li, Tingwen Huang
core   +1 more source

A Weak Comparison Principle for Reaction-Diffusion Systems [PDF]

, 2012
We prove a weak comparison principle for a reaction-diffusion system without uniqueness of solutions. We apply the abstract results to the Lotka-Volterra system with diffusion, a generalized logistic equation, and to a model of fractional-order chemical ...
José Valero
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

An eigenvalue problem for the infinity-Laplacian

Electronic Journal of Differential Equations, 2013
In this work, we study an eigenvalue problem for the infinity-Laplacian on bounded domains. We prove the existence of the principal eigenvalue and a corresponding positive eigenfunction.
Tilak Bhattacharya, Leonardo Marazzi
doaj  

Oscillation Theorems of Fourth-Order Differential Equations with a Variable Argument Using the Comparison Technique

Axioms
In this study, we establish new oscillation criteria for solutions of the fourth-order differential equation (aϕuu‴)+q(u∘h)=0, which is of a functional type with a delay.
Osama Moaaz, Wedad Albalawi, Refah Alotaibi   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source