Results 81 to 90 of about 7,566,926 (308)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Note on a role for entire functions of the classes P and P*

International Journal of Mathematics and Mathematical Sciences, 1981
We use the B and B* operators of Levin on the Classes P and P* and a comparison principle to prove a Gauss-Lucas Theorem for differential operators. The connection with the determination of final sets for differential operators is then clarified.
C. L. Prather
doaj   +1 more source

Theoretical Principles in Interurban Simulation Models: A Comparison

Environment and Planning A: Economy and Space, 2013
Agent-based models are increasingly used by urban specialists, supplanting the simulation models using differential equations which were more popular earlier. These models already made reference to the theories of self-organisation and to mechanisms of evolution not so far from those used today to describe the emergence of macroscopic properties or ...
Denise Pumain, Lena Sanders
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Useful Results for the Qualitative Analysis of Generalized Hattaf Mixed Fractional Differential Equations with Applications to Medicine

Computation
Most solutions of fractional differential equations (FDEs) that model real-world phenomena in various fields of science, industry, and engineering are complex and cannot be solved analytically.
Khalid Hattaf
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A singular ODE related to quasilinear elliptic equations

Electronic Journal of Differential Equations, 2000
We consider a quasilinear elliptic problem with the natural growth in the gradient. Existence, non-existence, uniqueness, and qualitative properties of positive solutions are obtained. We consider both weak and strong solutions.
Luka Korkut, Mervan Pasic, Darko Zubrinic   +2 more
doaj  

Parabolic Biased Infinity Laplacian Equation Related to the Biased Tug-of-War

Advanced Nonlinear Studies, 2019
In this paper, we study the parabolic inhomogeneous β-biased infinity Laplacian equation arising from the β-biased tug-of ...
Liu Fang, Jiang Feida
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Comparison Principles for the p-Laplacian Operator

Journal of Mathematical Sciences, 2014
In this paper the author proves new comparison principles for the \(p\)-Laplace operator, both in bounded and in unbounded domains. In bounded domains he applies an approach already developed in the literature for the case where \(1 < p\leq 2\), and extends it to the case \(p > 2\), using measure theory.
openaire   +3 more sources