Results 71 to 80 of about 690,408 (301)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The striatal compartments, striosome and matrix, are embedded in largely distinct resting-state functional networks

Frontiers in Neural Circuits
The striatum is divided into two interdigitated tissue compartments, the striosome and matrix. These compartments exhibit distinct anatomical, neurochemical, and pharmacological characteristics and have separable roles in motor and mood functions. Little
Alishba Sadiq, Adrian T. Funk, Jeff L. Waugh   +2 more
doaj   +1 more source

Fraction of total perfusion to the low ventilation-perfusion () compartment and value for high compartment in relation to value for low compartment.

, 2022
Results shown for patients 2–5. Some values off-scale for higher values of for the low compartment. Differences between measured and calculated arterial partial pressures for CO2 and O2 -2 mmHg for all distributions illustrated.
Nayia Petousi (3682708), Peter A. Robbins (7948766), Haopeng Xu (5504573)   +2 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Regional-scale biogeographical patterns of soil- and root-associated microbial communities across nine planted Chinese fir forests

mSphere
Chinese fir (Cunninghamia lanceolata) is an economically important plantation tree species. Gaining insights into the belowground microbiome of Chinese fir is critical for optimizing plantation management and enhancing timber production.
Feihua Zhou, Hanshuo Zhang, Wen Zhong, Hao Yang, Luhong Zhou, Zhi-Jie Yang, Yalin Hu, Yong Zheng   +7 more
doaj   +1 more source

Compartmentalization and Cell Division through Molecular Discreteness and Crowding in a Catalytic Reaction Network

Life, 2014
Explanation of the emergence of primitive cellular structures from a set of chemical reactions is necessary to unveil the origin of life and to experimentally synthesize protocells.
Atsushi Kamimura, Kunihiko Kaneko
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Pathways of host cell exit by intracellular pathogens

Microbial Cell, 2018
Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to barrier penetration, tissue dissemination, inflammation, and pathogen transmission.
Antje Flieger, Freddy Frischknecht, Georg Häcker, Mathias W. Hornef, Gabriele Pradel   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source