Results 71 to 80 of about 534,824 (258)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Pathways of host cell exit by intracellular pathogens

Microbial Cell, 2018
Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to barrier penetration, tissue dissemination, inflammation, and pathogen transmission.
Antje Flieger, Freddy Frischknecht, Georg Häcker, Mathias W. Hornef, Gabriele Pradel   +4 more
doaj   +1 more source

Fat Embolism Syndrome Mimicking a COVID-19 Infection

Case Reports in Critical Care, 2021
Fat embolism syndrome (FES) is a multiple organ disorder that can appear after pelvic and long bone fractures. The most common clinical finding is hypoxia, accompanied by diffuse petechiae, alveolar infiltrates, altered mental status, fever, polypnea ...
Alexandru Leonard Alexa, Adela Hilda Onutu   +1 more
doaj   +1 more source

Assessment of timber extraction distance and skid road network in steep karst terrain [PDF]

, 2017
This study aims to define a simple and effective method to calculate skidding distances on steep karst terrain, rich in ground obstacles (stoniness and rockiness) to support decision planning of secondary and primary forest infrastructure network for ...
\u110uka, Andreja, Grigolato, Stefano, Papa, Ivica, Pentek, Tibor, Por\u161insky, Tomislav   +4 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Stability indicator for defining environmental and protective requirements for landscape ecosystems

Journal of Environmental Engineering and Landscape Management
Methodological aspects of assessing harmful impacts on the natural environment are presented, aimed at determining the indicator of ecosystem stability.
Chengjun Zhou, Taras Boyko, Mariia Ruda, Alla Shybanova, Elvira Dzhumelia, Orest Kochan, Mariana Levkiv   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Assessment of the microbial community in the cathode compartment of a plant microbial fuel cell [PDF]

, 2013
Introduction: In plant microbial fuel cells (plant-MFCs) living plants and microorganisms form an electrochemical unit able to produce clean and sustainable electricity from solar energy.
Arends, Jan, Hartmann, Anton, Picot, Matthieu, Rothballer, Michael, Sieper, Tina, Strik, David   +5 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multiple-compartment venting program [PDF]

, 1975
Computer program solves time-dependent energy and state equations for gas reservoirs, using the solutions of conductor conservation equations as mass and energy rate changes to ...
Leblanc, L. P.
core   +1 more source