Results 91 to 100 of about 690,408 (301)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Carbapenemase Producing Enterobacterales in Romania: Investigating the Origins

Romanian Journal of Laboratory Medicine, 2020
Carbapenemase-producing Enterobacterales (CPE) have emerged and spread in Romania since 2010. According to the reports of the EuSPACE (European survey of carbapenemase-producing Enterobacteriaceae) the epidemio-logical stage of the CPE expansion in ...
Molnár Szabolcs, Vas Krisztina Eszter, Székely Edit   +2 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Endoscopic Compartment Release for Chronic Exertional Compartment Syndrome

Arthroscopy Techniques, 2013
Abstract Exertional compartment syndrome of the leg is a condition that can cause chronic debilitating pain in active persons during a variety of aerobic activities. Nonoperative treatments using stretching protocols and activity modifications are often unsuccessful, and thus several operative
Justin R. Knight, M.D., Marissa Daniels, B.A., William Robertson, M.D.   +2 more
openaire   +3 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Differential Effects of Wilt Disease on Arbuscular Mycorrhiza Fungi Communities in Roots and Rhizosphere Soil of Ammopiptanthus mongolicus

Agronomy
Ammopiptanthus mongolicus is a rare tertiary relic evergreen broad-leaved shrub that is seriously threatened by Fusarium wilt disease caused by Fusarium verticillioides.
Rui Yang, Manmei Wu, Jianli Liu, Hui Lyu, Yijia Chen, Xiaolei Wang, Shuihong Chen, Binbin Si   +7 more
doaj   +1 more source

MULTIPLE-FUNCTION ACTIVITY OF THE PREPARATION ARTAFIDIN

В мире научных открытий, 2017
The article presents test results of the preparation Artafidin that fights parasitic fauna of plants, animals and birds. Artafidin effectiveness against various kinds of aphids has been estimated 96.5-100% on horticultural crops, 97.4-98% on melons and ...
Lubov Demianovna Shamanskaya, Evgenii Ivanovich Butakov   +1 more
doaj   +1 more source

Compartment distribution.

, 2014
This table shows that the compartment distribution is severely skewed. The first column is the cellular compartment; the second and third columns are the number and percentage of sequences in each cellular compartment of the dataset I, while the fourth ...
Tao Song (130854), Hong Gu (68558)
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source