Results 111 to 120 of about 534,824 (258)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Improved method of using paraformaldehyde as a disinfectant [PDF]

open access: yes, 1971
Paraformaldehyde decreases required enclosed compartment disinfectant time and temperature by vaporizing powdered material from water slurry. Fire and explosion hazard at lower temperature is reduced. Total mixture evaporation occurs at plate temperature
Milner, J. F.
core   +1 more source

Unpredictable solutions of compartmental quasilineardifferential equations

open access: bronze, 2023
Marat Akhmet   +2 more
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Imaging of Pelvic Floor Dysfunction

open access: yesJournal of Gastrointestinal and Abdominal Radiology
The pelvic floor, which is divided into anterior, middle, and posterior compartments, receives support from muscles, endopelvic fascia, and ligaments that support the pelvic organs and prevent organ prolapse.
Anu Eapen   +9 more
doaj   +1 more source

Erratum to: A new approach to the compartmental analysis in pharmacokinetics: fractional time evolution of diclofenac [PDF]

open access: bronze, 2010
Jovan Popović   +5 more
openalex   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Method and apparatus for rebalancing a REDOX flow cell system [PDF]

open access: yes
A rebalance cell is provided for a REDOX electrochemical system of the type with anode and cathode fluids which are aqueous HC1 solutions with two metal species in each. The rebalance cell has a cathode compartment and a chlorine compartment separated by
Gahn, R. F.
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

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