Results 111 to 120 of about 665,350 (278)

Inositol phosphatase SHIP1 is a primary target of miR-155 [PDF]

, 2009
MicroRNA-155 (miR-155) has emerged as a critical regulator of immune cell development, function, and disease. However, the mechanistic basis for its impact on the hematopoietic system remains largely unresolved.
Baltimore, David, Chaudhuri, Aadel A., O'Connell, Ryan M., Rao, Dinesh S.   +3 more
core   +3 more sources

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

Risk analysis for RoPax vessels [PDF]

, 2008
The paper presents the results of a recent risk analysis study for RoPax vessels, carried out as part of the activities of the SAFEDOR Integrated Project.
Konovessis, Dimitris, Mermiris, Georgios, Vassalos, Dracos   +2 more
core   +1 more source

Pharmacomicrobiomics

Clinical Pharmacology &Therapeutics, EarlyView.
Oral medications encounter gut commensal microbes that participate directly and indirectly in drug effects through metabolism, interactions with drug metabolites, or production of substrates that compete with drugs for drug‐metabolizing enzymes, consequently influencing drug pharmacokinetics.
Naomi Gronich, Naama Geva‐Zatorsky, Rachel Herren, Libusha Kelly, Ziv Cohen, Haiying Zhou, Yi‐Ching Chen, Khalid Shah, Talin A. Robinson‐Catala, Grecia Frisby, Jason H. Karnes, Lisl Shoda   +11 more
wiley   +1 more source

Heat Transfer Characteristics of Bulkhead Penetration Piece for A60 Class Compartment II: Fire Resistance Test for Piece Material and Insulation Types [PDF]

한국해양공학회지, 2019
In the case of a fire accident on a ship or an offshore plant, the design of the bulkhead penetration piece must be verified via a fire test procedure (FTP), as specified by the Maritime Safety Committee (MSC). The purpose of this study is to verify both
Woo-Chang Park, Chang Yong Song
doaj   +1 more source

Risk evaluation for RoPax vessels [PDF]

, 2008
The paper presents the results of a recent risk evalua-tion study for RoPax vessels, carried out as part of the activities of the SAFEDOR Integrated Project.
Konovessis, Dimitris, Vassalos, Dracos
core   +1 more source

Identification of Candidate Blood Biomarkers of Recombinant Human Erythropoietin Administration Using Targeted Polar Metabolomics by HILIC‐MS/MS

Drug Testing and Analysis, EarlyView.
Using targeted HILIC‐MS/MS metabolomics, inosine and hypoxanthine were identified as potential biomarkers of EPO administration. Their consistent and sensitive plasma responses highlight their promise for inclusion in the Athlete Biological Passport (ABP), warranting further investigation to enhance anti‐doping detection strategies. ABSTRACT Increasing
Olivier Salamin, Lejla Ramic, Raul Nicoli, Serge Rudaz, Davy Guillarme, Tiia Kuuranne   +5 more
wiley   +1 more source

Study on the flooding characteristics of damaged barges with dynamic explosive deformation

International Journal of Naval Architecture and Ocean Engineering
Dynamic explosion in a compartment damages the structure, resulting in flooding and even sinking of the ship. To study the flooding characteristics of damaged compartments and floating states of the hull under deformation of the bulkhead caused by ...
Hongtao Hu, Xiaobin Li, Caineng Wang, Changkyu Rheem, Wei Chen   +4 more
doaj   +1 more source

Review of ship arrangement design using optimization methods

Journal of Computational Design and Engineering
This study presents a comprehensive review of various research efforts aimed at optimizing ship arrangement design. A detailed comparative analysis was conducted on studies that approached ship arrangement design from an optimization perspective ...
Ki-Su Kim, Myung-Il Roh
semanticscholar   +1 more source

Carbon Storage in Fold‐and‐Thrust Belts: An Overlooked Gigatonne Storage Opportunity

Greenhouse Gases: Science and Technology, EarlyView.
ABSTRACT This study presents numerical investigations of the trapping characteristics of fold‐and‐thrust belt structures, defining three carbon capture and storage (CCS) play types that could be used to store commercial volumes (millions of tonnes) of CO2.
Lars W. Koehn, Ethan W. Conley, Isabella Andrade, Philip S. Prince, Ryan M. Pollyea   +4 more
wiley   +1 more source