Results 111 to 120 of about 45,997 (273)

A stochastic model of cell proliferation and death across a sequence of compartments [PDF]

open access: yesarXiv, 2021
Cells of the human body have nearly identical genome but exhibit very different phenotypes that allow them to carry out specific functions and react to changes in their surrounding environment. This division of labour is achieved by cellular division and cellular differentiation, events which lead to a population of cells with unique characteristics ...
arxiv  

Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation

open access: yesVIEW, EarlyView.
Fire‐related smoke inhalation‐induced acute lung injury (SI‐ALI) poses a significant public health risk, yet effective treatments are limited due to the lack of suitable models. This study developed a more realistic model of SI‐ALI using organ‐on‐a‐chip and organoid technologies, identified key molecules such as catechol‐O‐methyltransferase and ...
Junmin Li   +12 more
wiley   +1 more source

Multi-compartmental modeling for Gd-EOB-DTPA using sparse human DCE-MRI data [PDF]

open access: yesarXiv, 2023
Purpose: To derive kinetic equations for multi-compartmental contrast agent distribution from first principles and apply it to two and three compartments for Gd-EOB-DTPA using low time resolution human liver DCE-MRI data. Methods: The continuity and diffusion equation were combined and used to derive a general form for differential equations ...
arxiv  

Inflatable honeycomb Patent [PDF]

open access: yes, 1965
Inflatable honeycomb panel element for lightweight structures usable in space stations and other ...
Schnitzer, E.
core   +1 more source

Parametric optimization of FPSO hull dimensions for Brazil field using sophisticated stability and hydrodynamic calculations

open access: yesInternational Journal of Naval Architecture and Ocean Engineering, 2021
In this study, hull dimensions of an FPSO were optimized to maximize its operability at Brazil field. In contrast with the previous works which have used simplified models to evaluate some indicators related to stability and hydrodynamic performances of ...
Jonghun Lee   +3 more
doaj  

Dynamics Finite Element for Ship Damage Collision Analysis [PDF]

open access: yes, 2017
¾ Along with the growing fleet of vessels, ship collision accident cases are becoming more frequent. It is unavoidable that the rapid shipping due to the number of vessels that operate relatively large and the ship is waiting for the loading and ...
Aryawan, Wasis Dwi   +3 more
core   +2 more sources

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle

open access: yesAging Cell, EarlyView.
Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targets collagen remodeling and stem cell function‐related genes.
Toby L. Chambers   +16 more
wiley   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

open access: yesThe FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

An AI‐Assisted Framework for Improving Innovativeness in Small Businesses: A Human–AI Collaboration Perspective

open access: yesInformation Systems Journal, EarlyView.
ABSTRACT Innovation is crucial for small businesses to remain competitive and adaptable in dynamic markets. Recent advancements in AI, particularly machine learning and natural language processing, offer promising tools for enhancing product innovation.
Kristijan Mirkovski   +4 more
wiley   +1 more source

Early phase pharmacokinetics but not pharmacodynamics are influenced by propofol infusion rate [PDF]

open access: yes, 2009
Background: Conventional compartmental pharmacokinetic models wrongly assume instantaneous drug mixing in the central compartment, resulting in a flawed prediction of drug disposition for the first minutes, and the flaw affects pharmacodynamic modeling ...
Hagihira, Satoshi   +5 more
core   +2 more sources

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