Results 11 to 20 of about 222,490 (305)

Current State of Compassionate Phage Therapy

Viruses, 2019
There is a current unmet medical need for the treatment of antibiotic-resistant infections, and in the absence of approved alternatives, some clinicians are turning to empirical ones, such as phage therapy, for compassionate treatment.
Shawna McCallin, Jessica C. Sacher, Jan Zheng, Benjamin K. Chan   +3 more
doaj   +3 more sources

Compassionate Use of Remdesivir in Covid-19

New England Journal of Medicine, 2020
Jiayuan, Wu, Bin, Wu, Tianwen, Lai
openaire   +8 more sources

Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report. [PDF]

Lancet, 2023
Mohiuddin MM, Singh AK, Scobie L, Goerlich CE, Grazioli A, Saharia K, Crossan C, Burke A, Drachenberg C, Oguz C, Zhang T, Lewis B, Hershfeld A, Sentz F, Tatarov I, Mudd S, Braileanu G, Rice K, Paolini JF, Bondensgaard K, Vaught T, Kuravi K, Sorrells L, Dandro A, Ayares D, Lau C, Griffith BP.   +26 more
europepmc   +2 more sources

Compassionate Use of Yuanjiang Decoction, a Traditional Chinese Medicinal Prescription, for Symptomatic Bradyarrhythmia

Frontiers in Pharmacology, 2022
Background: No effective medication is available for symptomatic bradyarrhythmia, particularly in low socioeconomic status (SES) population.Objective: To explore the safety and efficacy of Yuanjiang decoction, a traditional Chinese medicinal prescription,
Zhang Wan-Tong, Zhang Wan-Tong, Zhang Wan-Tong, Zhu Bao-Chen, Liu Zhao, Wang Xu-Jie, Wang Xu-Jie, Wang Xu-Jie, Gao Rui, Gao Rui, Gao Rui, Xiao Ning, Tang Wei, Wu Yu-Fei, Phoebe Miles, Weng Wei-Liang, Weng Wei-Liang, Lin Hao-Xiang, Li Qiu-Yan, Li Qiu-Yan, Li Qiu-Yan   +20 more
doaj   +1 more source

Novel Antiviral Strategies in the Treatment of COVID-19: A Review

Microorganisms, 2020
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2), is still a global public health problem for humans.
Shiu-Jau Chen, Shao-Cheng Wang, Yuan-Chuan Chen   +2 more
doaj   +1 more source

Compassionate use of orphan drugs [PDF]

Orphanet Journal of Rare Diseases, 2015
EU regulation 726/2004 authorises manufacturers to provide drugs to patients on a temporary basis when marketing authorisation sought centrally for the entire EU is still pending. Individual Member States retain the right to approve and implement such 'compassionate use' programmes which companies will usually provide for free.
Hyry, Hanna I., Manuel, Jeremy, Cox, Timothy M., Roos, Jonathan C. P.   +3 more
openaire   +2 more sources

The High “Cost” of Experimental Drugs Obtained Through Health Litigation in Brazil

Frontiers in Pharmacology, 2020
BackgroundBrazilian patients have legal right to access unlicensed medicines undergoing clinical research, if there is evidence of efficacy and safety. This study investigated the occurrence of serious adverse events related to very high-cost medicines ...
Ricardo Eccard da Silva, Elisangela da Costa Lima, Maria Rita C. G. Novaes, Maria Rita C. G. Novaes, Claudia G. S. Osorio-de-Castro   +4 more
doaj   +1 more source

Compassionate Use of the ROCK Inhibitor Fasudil in Three Patients With Amyotrophic Lateral Sclerosis

Frontiers in Neurology, 2020
The Rho kinase (ROCK) inhibitor Fasudil is a promising drug for a disease-modifying therapy of amyotrophic lateral sclerosis (ALS). In preclinical models, Fasudil was shown to increase motor neuron survival, inhibit axonal degeneration, enhance axonal ...
Jan C. Koch, Josua Kuttler, Fabian Maass, Teresa Lengenfeld, Eirini Zielke, Mathias Bähr, Paul Lingor, Paul Lingor   +7 more
doaj   +1 more source

An analysis of common ethical justifications for compassionate use programs for experimental drugs [PDF]

, 2016
BACKGROUND: When a new intervention or drug is developed, this has to pass through various phases of clinical testing before it achieves market approval, which can take many years.
Raus, Kasper
core   +1 more source

Off-label prescription of drugs at hospital [PDF]

Farmacia Hospitalaria, 2016
Objectives: To develop a procedure for management of off-label medications, and to analyze the treatments, indications, and hospital units which will request them more frequently, as well as which variables will have an impact on the authorization ...
Vicente Arocas Casañ, Jaime Mateo Carmona, Olga García Molina, Mº Ángeles Fernández de Palencia Espinosa, Mª José Blázquez Álvarez Espinosa, Mª Amelia de la Rubia Nieto, Jesús del Río García   +6 more
doaj   +1 more source