Results 91 to 100 of about 425,534 (313)

Vertical differentiation, network externalities and compatibility decisions : an alternative approach [PDF]

We characterize the equilibrium of a game in vertically differentiated market which exhibits network externalities. There are two firms, an incumbent and a potential entrant.
Rim Lahmandi-Ayed, Hend Ghazzai
core  

The impact of compatibility on innovation in markets with network effects

, 2019
© 2019 Informa UK Limited, trading as Taylor & Francis Group. This article analyses the relationship between compatibility and innovation in markets with network effects using a model of competition with endogenous R&D, commercialization and ...
Bond-Smith, Steven
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Table_1_Overcoming Cabbage Crossing Incompatibility by the Development and Application of Self-Compatibility-QTL- Specific Markers and Genome-Wide Background Analysis.XLS

, 2019
Cabbage hybrids, which clearly present heterosis vigor, are widely used in agricultural production. We compared two S5 haplotype (Class II) cabbage inbred-lines 87–534 and 94–182: the former is highly SC while the latter is highly SI; sequence analysis ...
Yang Hu (315392), Yuqian Xue (6398405), Honghao Lv (800307), Yangyong Zhang (537091), Mu Zhuang (537090), Zhansheng Li (537088), Limei Yang (223781), Fengqing Han (6398402), Yumei Liu (286628), Zhiliang Xiao (6398399), Zhiyuan Fang (537089), Yong Wang (12837)   +11 more
core   +1 more source

Association of circulating branched-chain amino acids with risk of pre-diabetes: a systematic review and meta-analysis [PDF]

PeerJ
Objective Recent investigations have looked at the systemic concentrations of branched-chain amino acids (BCAA), which they consider prospective indicators for health conditions and the likelihood of chronic diseases.
Yu Wang, Jiang-Hong Xiao, Xi-Mei Zhang, Wen-Xiao Wang, Qiao Zhang, Yu-Ping Tang, Shi-Jun Yue   +6 more
doaj   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Image_2_Overcoming Cabbage Crossing Incompatibility by the Development and Application of Self-Compatibility-QTL- Specific Markers and Genome-Wide Background Analysis.JPEG

, 2019
Cabbage hybrids, which clearly present heterosis vigor, are widely used in agricultural production. We compared two S5 haplotype (Class II) cabbage inbred-lines 87–534 and 94–182: the former is highly SC while the latter is highly SI; sequence analysis ...
Yang Hu (315392), Yuqian Xue (6398405), Honghao Lv (800307), Yangyong Zhang (537091), Mu Zhuang (537090), Zhansheng Li (537088), Limei Yang (223781), Fengqing Han (6398402), Yumei Liu (286628), Zhiliang Xiao (6398399), Zhiyuan Fang (537089), Yong Wang (12837)   +11 more
core   +1 more source

Susceptibility analysis of complex systems [PDF]

, 1990
A study of electromagnetic coupling effects on systems containing distributed elements and lumped linear components is presented. The structure is decomposed into sections containing multiconductor transmission lines and interconnection blocks holding ...
V. Daniele, Pignari, S., F.G. Canavero, Pignari S., S. Pignari, Daniele, Vito, Canavero, Flavio   +6 more
core   +1 more source