Results 71 to 80 of about 520,175 (264)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Multihoming and compatibility [PDF]
This paper analyzes the consequences of multihoming on private and social incentives for compatibility. Multihoming occurs in our model when consumers buy from both of two competing firms so as to capture network benefits.
Toker Doganoglu, Julian Wright
core
A simple and rapid method to determine vegetative compatibility groups in fungi [PDF]
, 2009 Vegetative compatibility in fungi reflects phenotypic differences (or similarity) among individuals representing the population of a species (Leslie 1993). Thus, individuals (genotypes) of a fungal species having the same heterokaryon (het) or vegetative
Wingfield, B.D. +3 more
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A Balanced-to-Unbalanced Hybrid Ring With Arbitrary Power Division Ratio
IEEE Access, 2018 This paper presents a new balanced-to-unbalanced (BTU) hybrid ring with arbitrary power division ratio. Standard S-parameters and mixed-mode S-parameters are adopted to describe the performance requirements of the BTU hybrid ring.
Lin Li, Lin Sheng Wu, Jun-Fa Mao
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Vertical differentiation, network externalities and compatibility decisions : an alternative approach [PDF]
We characterize the equilibrium of a game in vertically differentiated market which exhibits network externalities. There are two firms, an incumbent and a potential entrant.
Rim Lahmandi-Ayed, Hend Ghazzai
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
IEEE Access, 2018 In this paper, a multifunctional 180° hybrid coupler is proposed, with an ultra-wideband filtering response and a super wide upper stopband. The component, realized with double-sided parallel-strip line (DSPSL), is built up on the basis of a ...
Qiu-Sheng Shen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source